A review of biophysical strategies to investigate protein-ligand binding: What have we employed?
Z Zhao, L Zhao, C Kong, J Zhou, F Zhou - International Journal of Biological …, 2024 - Elsevier
The protein-ligand binding frequently occurs in living organisms and plays a crucial role in
the execution of the functions of proteins and drugs. It is also an indispensable part of drug …
the execution of the functions of proteins and drugs. It is also an indispensable part of drug …
Discovery of potent heat shock protein 90 (Hsp90) inhibitors: structure-based virtual screening, molecular dynamics simulation, and biological evaluation
Y Xu, Y Zou, S Zhou, MM Niu, Y Zhang, J Li… - Journal of Enzyme …, 2023 - Taylor & Francis
Abstract Heat shock protein 90 (Hsp90) is considered an attractive therapeutic target for
cancer treatment due to its high expression in many cancers. In this study, four potent Hsp90 …
cancer treatment due to its high expression in many cancers. In this study, four potent Hsp90 …
Ammonia scavenger and glutamine synthetase inhibitors cocktail in targeting mTOR/β-catenin and MMP-14 for nitrogen homeostasis and liver cancer
A Elmetwalli, A Nageh, AI Youssef, M Youssef… - Medical Oncology, 2023 - Springer
The glutamine synthetase (GS) facilitates cancer cell growth by catalyzing de novo
glutamine synthesis. This enzyme removes ammonia waste from the liver following the urea …
glutamine synthesis. This enzyme removes ammonia waste from the liver following the urea …
[HTML][HTML] Marine-derived sea urchin compounds as potential anti-cancer drug candidate against colorectal cancer: In silico and in vitro studies
MHR Molla, MO Aljahdali - Saudi Journal of Biological Sciences, 2023 - Elsevier
Sea urchin-derived compounds are potential candidates for the development of effective
drugs for the treatment of cancer diseases. In this study, 19 compounds derived from sea …
drugs for the treatment of cancer diseases. In this study, 19 compounds derived from sea …
[HTML][HTML] The crosstalk between phytotherapy and bioinformatics in the management of cancer
A Elbasyouni, SW Kpordze, HS Hussein… - Recent Advances in …, 2023 - intechopen.com
Natural products and medicinal plants have been extremely important contributors to the
field of drug development due to their ability to bind to and change cellular targets that have …
field of drug development due to their ability to bind to and change cellular targets that have …
In silico molecular study of hepatitis B virus X protein as a therapeutic target
Y Hamadalnil, HN Altayb - Journal of Biomolecular Structure and …, 2024 - Taylor & Francis
The Hepatitis B virus is a leading cause of liver cirrhosis and hepatocellular carcinoma. HBx
viral protein is considered a contributor to pathogenesis and hepatocarcinogenesis. This …
viral protein is considered a contributor to pathogenesis and hepatocarcinogenesis. This …
Integrated structure model-based virtual screening approaches identified anti-cancer agents against prostate cancer by targeting MAOB protein
Background Flavin monoamine oxidase gene encodes a protein (MAOB) that forms a part of
the flavin monoamine oxidase family in the outer membrane of mitochondria. It plays a role …
the flavin monoamine oxidase family in the outer membrane of mitochondria. It plays a role …
Cheminformatics-based identification of phosphorylated RET tyrosine kinase inhibitors for human cancer
Background Rearranged during transfection (RET), an oncogenic protein, is associated with
various cancers, including non-small-cell lung cancer (NSCLC), papillary thyroid cancer …
various cancers, including non-small-cell lung cancer (NSCLC), papillary thyroid cancer …
Exploring the Antibacterial Potential of Artemisia judaica Compounds Targeting the Hydrolase/Antibiotic Protein in Klebsiella pneumoniae: In Vitro and In Silico …
FA Alshammari - Pharmaceuticals, 2024 - mdpi.com
Carbapenem antibiotic resistance is an emerging medical concern. Bacteria that possess
the Klebsiella pneumoniae carbapenemase (KPC) protein, an enzyme that catalyzes the …
the Klebsiella pneumoniae carbapenemase (KPC) protein, an enzyme that catalyzes the …
One-pot domino synthesis of 1H-isochromene and pyran carbonitrile from pyrazole aldehyde derivatives as potential anti-diabetic and antioxidant targets
The compounds, 1H-Isochromene and pyran carbonitrile were synthesized from the
pyrazole aldehyde derivatives through efficient synthetic routes and characterization was …
pyrazole aldehyde derivatives through efficient synthetic routes and characterization was …