Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFR WT and EGFR T790M
A new series of pyrimidine-5-carbonitrile derivatives has been designed as ATP mimicking
tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR). These compounds …
tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR). These compounds …
New quinoxaline-2 (1 H)-ones as potential VEGFR-2 inhibitors: Design, synthesis, molecular docking, ADMET profile and anti-proliferative evaluations
Eleven new quinoxaline derivatives were designed and synthesized as modified VEGFR-2
inhibitors of our previous work. The synthesized compounds were tested against three …
inhibitors of our previous work. The synthesized compounds were tested against three …
Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro, and SAR …
C Ma, MS Taghour, A Belal, ABM Mehany… - Frontiers in …, 2021 - frontiersin.org
Guided by the structural optimization principle and the promising anticancer effect of the
quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and …
quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and …
New possibilities of the Mannich reaction in the synthesis of N-, S,N-, and Se,N-heterocycles
VV Dotsenko, KA Frolov, EA Chigorina… - Russian chemical …, 2019 - Springer
The review summarizes the results obtained by our research group over the past 15 years in
chemistry of N-, S, N-, and Se, N-heterocycles resulted from aminomethlation of a wide …
chemistry of N-, S, N-, and Se, N-heterocycles resulted from aminomethlation of a wide …
Discovery of new quinoxaline-2 (1H)-one-based anticancer agents targeting VEGFR-2 as inhibitors: Design, synthesis, and anti-proliferative evaluation
VEGF/VEGFR2 pathway is the crucial therapeutic target in the treatment of cancer. So that, a
new series of quinoxaline-2 (1H)-one derivatives were designed and synthesized. The …
new series of quinoxaline-2 (1H)-one derivatives were designed and synthesized. The …
Design, synthesis, and biological evaluation of new challenging thalidomide analogs as potential anticancer immunomodulatory agents
Thalidomide and its analogs are immunomodulatory drugs that inhibit the production of
certain inflammatory mediators associated with cancer. In the present work, a new series of …
certain inflammatory mediators associated with cancer. In the present work, a new series of …
Tanshinone IIA synergistically enhances the antitumor activity of doxorubicin by interfering with the PI3K/AKT/mTOR pathway and inhibition of topoisomerase II: in vitro …
Triple-negative breast cancer (TNBC) subtype is one of the most aggressive tumors with no
definite receptor, hence has a limited number of effective chemotherapeutics. Doxorubicin …
definite receptor, hence has a limited number of effective chemotherapeutics. Doxorubicin …
Design, synthesis, and anti-proliferative evaluation of new quinazolin-4 (3H)-ones as potential VEGFR-2 inhibitors
K El-Adl, AGA El-Helby, RR Ayyad, HA Mahdy… - Bioorganic & Medicinal …, 2021 - Elsevier
Inhibiting VEGFR-2 has been set up as a therapeutic strategy for treatment of cancer. Thus,
nineteen new quinazoline-4 (3H)-one derivatives were designed and synthesized …
nineteen new quinazoline-4 (3H)-one derivatives were designed and synthesized …
Design, molecular docking, in vitro, and in vivo studies of new quinazolin-4 (3H)-ones as VEGFR-2 inhibitors with potential activity against hepatocellular carcinoma
A series of new VEGFR-2 inhibitors were designed, synthesized and evaluated for their anti-
proliferative activities against hepatocellular carcinoma (HepG-2 cell line). Compound 29 b …
proliferative activities against hepatocellular carcinoma (HepG-2 cell line). Compound 29 b …
Discovery of new quinazolin-4 (3H)-ones as VEGFR-2 inhibitors: Design, synthesis, and anti-proliferative evaluation
IH Eissa, AGA El-Helby, HA Mahdy, MM Khalifa… - Bioorganic …, 2020 - Elsevier
Sixteen novel quinazoline-based derivatives were designed and synthesized via
modification of the VEGFR-2 reported inhibitor 7 in order to increase the binding affinity of …
modification of the VEGFR-2 reported inhibitor 7 in order to increase the binding affinity of …