Salivary glands produce and secrete saliva, which is essential for maintaining oral health
and overall health. Understanding both the unique structure and physiological function of …

Our understanding of the molecular events underpinning the development of mammalian
organ systems has been increasing rapidly in recent years. With the advent of new and …

Understanding the dynamic transcriptional landscape throughout organ development will
provide a template for regenerative therapies. Here, we generated a single-cell RNA …

Permanent damage to the salivary glands and resulting hyposalivation and xerostomia have
a substantial impact on patient health, quality of life, and healthcare costs. Currently, patients …

Salivary proteins are essential for maintaining health in the oral cavity and proximal
digestive tract, and they serve as potential diagnostic markers for monitoring human health …

Salivary gland hypofunction causes significant morbidity and loss of quality of life for head
and neck cancer patients treated with radiotherapy. Preventing hypofunction is an unmet …

Exocrine acinar cells in salivary glands (SG) are critical for oral health and loss of functional
acinar cells is a major clinical challenge. Fibroblast growth factor receptors (FGFR) are …

Salivary glands exert exocrine secretory function to provide saliva for lubrication and
protection of the oral cavity. Its epithelium consists of several differentiated cell types …

The development of the mouse salivary gland involves a tip-driven process of branching
morphogenesis that takes place in concert with differentiation into acinar, myoepithelial, and …

Acinar cells are the principal secretory units of multiple exocrine organs. A single-cell,
layered, lumenized acinus forms from a large cohort of epithelial progenitors that must …