Up-down regulation of HIF-1α in cancer progression

M Rashid, LR Zadeh, B Baradaran, O Molavi… - Gene, 2021 - Elsevier
Hypoxia induicible factor-1 alpha (HIF-1α) is a key transcription factor in cancer progression
and target therapy in cancer. HIF-1α acts differently depending on presence or absence of …

Molecular mechanisms of drug resistance

DB Longley, PG Johnston - The Journal of Pathology: A Journal …, 2005 - Wiley Online Library
Resistance to chemotherapy limits the effectiveness of anti‐cancer drug treatment. Tumours
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …

Mechanisms of multidrug resistance in cancer

JP Gillet, MM Gottesman - Multi-drug resistance in cancer, 2010 - Springer
The development of multidrug resistance (MDR) to chemotherapy remains a major
challenge in the treatment of cancer. Resistance exists against every effective anticancer …

p53 and breast cancer, an update

M Lacroix, RA Toillon, G Leclercq - Endocrine-related cancer, 2006 - erc.bioscientifica.com
p53 plays a key role in mediating cell response to various stresses, mainly by inducing or
repressing a number of genes involved in cell cycle arrest, senescence, apoptosis, DNA …

Influence of TP53 Gene Alterations and c-erbB-2 Expression on the Response to Treatment with Doxorubicin in Locally Advanced Breast Cancer

S Geisler, PE Lønning, T Aas, H Johnsen, Ø Fluge… - Cancer research, 2001 - AACR
Abstract TP53 status [mutations, immunostaining, and loss of heterozygosity (LOH)],
expression of c-erbB-2, bcl-2, and histological grading were correlated to the response to …

Prognostic molecular markers in early breast cancer

FJ Esteva, GN Hortobagyi - Breast cancer research, 2004 - Springer
A multitude of molecules involved in breast cancer biology have been studied as potential
prognostic markers. In the present review we discuss the role of established molecular …

[PDF][PDF] Chemoresistance in solid tumours

TR Wilson, DB Longley, PG Johnston - Annals of Oncology, 2006 - academia.edu
Drug resistance is a major factor that limits the effectiveness of chemotherapy. Tumours can
be intrinsically resistant prior to chemotherapy, or resistance may be acquired during …

Complete Sequencing of TP53 Predicts Poor Response to Systemic Therapy of Advanced Breast Cancer

EMJJ Berns, JA Foekens, R Vossen, MP Look… - Cancer Research, 2000 - AACR
TP53 has been implicated in regulation of the cell cycle, DNA repair, and apoptosis. We
studied, in primary breast tumors through direct cDNA sequencing of exons 2–11, whether …

Hypoxia-induced resistance to chemotherapy in cancer

LM Minassian, T Cotechini, E Huitema… - Hypoxia and Cancer …, 2019 - Springer
A major barrier to the successful management of cancer is the development of resistance to
therapy. Chemotherapy resistance can either be an intrinsic property of malignant cells …

[HTML][HTML] Resistance to cancer chemotherapeutic drugs is determined by pivotal microRNA regulators

M Geretto, A Pulliero, C Rosano… - American journal of …, 2017 - ncbi.nlm.nih.gov
Chemo-resistance, which is the main obstacle in cancer therapy, is caused by the onset of
drug-resistant cells in the heterogeneous cell population in cancer tissues. MicroRNAs …