Conspectus Protein folding and dynamics are controlled by an interplay of thermal and
viscosity effects. The effect of viscous drag through the solvent molecules is described by the …

Intrinsically disordered proteins (IDPs) and regions (IDRs) have emerged as key players
across many biological functions and diseases. Differently from structured proteins …

Biomolecular condensates formed via phase separation of proteins and nucleic acids are
thought to be associated with a wide range of cellular functions and dysfunctions. We dissect …

Membrane wetting by biomolecular condensates recently emerged as a key phenomenon in
cell biology, playing an important role in a diverse range of processes across different …

Fluorescence correlation spectroscopy and time-dependent fluorescence Stokes shift have
been employed to elucidate dynamics in different time scales, ranging from picoseconds to …

Protein loop dynamics have recently been recognized as central to enzymatic activity,
specificity and stability. However, the factors controlling loop opening and closing kinetics …

The impact of macromolecular crowding on biological macromolecules has been elucidated
through the excluded volume phenomenon and soft interactions. However, it has often been …

Barrier-crossing rates of biophysical processes, ranging from simple conformational
changes to protein folding, often deviate from the Kramers prediction of an inverse viscosity …

Myelin basic protein (MBP) is intrinsically disordered in solution and is considered as a
conformationally flexible biomacromolecule. Here, we present a study on perturbation of …

An exact solution of coarse-grained polymer models with fluctuating internal friction and
hydrodynamic interactions has not been proposed so far due to a one-to-all coupling …