Attacking pain at its source: new perspectives on opioids
The treatment of severe pain with opioids has thus far been limited by their unwanted central
side effects. Recent research promises new approaches, including opioid analgesics acting …
side effects. Recent research promises new approaches, including opioid analgesics acting …
Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors
Peripheral mediators can contribute to the development and maintenance of inflammatory
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …
PGE2 modulates the tetrodotoxin‐resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP‐protein kinase A cascade.
S England, S Bevan, RJ Docherty - The Journal of physiology, 1996 - Wiley Online Library
1. In current‐clamp recordings, 1 microM prostaglandin E2 (PGE2) increased the excitability
of neonatal rat dorsal root ganglion neurones. The current threshold for firing was reduced …
of neonatal rat dorsal root ganglion neurones. The current threshold for firing was reduced …
Peripheral mechanisms of pain and analgesia
This review summarizes recent findings on peripheral mechanisms underlying the
generation and inhibition of pain. The focus is on events occurring in peripheral injured …
generation and inhibition of pain. The focus is on events occurring in peripheral injured …
Modulation of TTX-R INa by PKC and PKA and their role in PGE2-induced sensitization of rat sensory neurons in vitro
MS Gold, JD Levine, AM Correa - Journal of Neuroscience, 1998 - Soc Neuroscience
A tetrodotoxin-resistant voltage-gated Na+ current (TTX-R I Na) appears to be the current
primarily responsible for action potential generation in the cell body and terminals of …
primarily responsible for action potential generation in the cell body and terminals of …
Modulation of peripheral sensory neurons by the immune system: implications for pain therapy
C Stein, H Machelska - Pharmacological reviews, 2011 - ASPET
The concept that the immune system can communicate with peripheral sensory neurons to
modulate pain is based mostly on documented interactions between opioid ligands and …
modulate pain is based mostly on documented interactions between opioid ligands and …
Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation
N Yoshimura, WC de Groat - Journal of Neuroscience, 1999 - Soc Neuroscience
The properties of bladder afferent neurons in L6 and S1 dorsal root ganglia of adult rats
were evaluated after chronic bladder inflammation induced by 2 week treatment with …
were evaluated after chronic bladder inflammation induced by 2 week treatment with …
Twenty years of dendrotoxins
AL Harvey - Toxicon, 2001 - Elsevier
Dendrotoxins are small proteins that were isolated 20 years ago from mamba (Dendroaspis)
snake venoms (Harvey, AL, Karlsson, E., 1980. Dendrotoxin from the venom of the green …
snake venoms (Harvey, AL, Karlsson, E., 1980. Dendrotoxin from the venom of the green …
Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network
The analgesic utility of opioid-based drugs is limited by the life-threatening risk of respiratory
depression. Opioid-induced respiratory depression (OIRD), mediated by the μ-opioid …
depression. Opioid-induced respiratory depression (OIRD), mediated by the μ-opioid …