Mitochondria are structurally and functionally distinct organelles that produce adenosine
triphosphate (ATP) through oxidative phosphorylation (OXPHOS), to provide energy to …

The oocyte is recognised as the largest cell in mammalian species and other multicellular
organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

Somatic cells accumulate genomic alterations with age; however, our understanding of
mitochondrial DNA (mtDNA) mosaicism remains limited. Here we investigated the genomes …

Bidirectional somatic cell–oocyte signaling is essential to create a changing intrafollicular
microenvironment that controls primordial follicle growth into a cohort of growing follicles …

Although mitochondria are best known for being the eukaryotic cell powerhouses, these
organelles participate in various cellular functions besides ATP production, such as calcium …

In mammals, seven members of the sirtuin protein family known as class III histone
deacetylase have been identified for their characteristic features. These distinguished …

Mitochondria play a vital role in embryo development. They are the principal site of energy
production and have various other critical cellular functions. Despite the importance of this …

This review considers how our understanding of preimplantation embryo metabolism has
progressed since the pioneering work on this topic in the late 1960s and early 1970s …

As women delay childbearing because of demographic and socioeconomic trends,
reproductive aging and ensuing ovarian dysfunction become increasingly more prevalent …