Background Patient-derived tumor models are the new standard for pre-clinical drug testing
and biomarker discovery. However, the emerging technology of primary pancreatic cancer …

Background Most uterine cervical high-risk human papillomavirus (HPV) infections are
transient, with only a small fraction developing into cervical cancer. Family aggregation …

Glycosylphosphatidylinositol (GPI) anchoring of proteins is a ubiquitous posttranslational
modification in eukaryotic cells. GPI-anchored proteins (GPI-APs) play critical roles in …

Recurrence of therapy-resistant tumors is a principal problem in solid tumor oncology,
particularly in ovarian cancer. Despite common complete responses to first line, platinum …

Altered regulation of endoplasmic reticulum (ER) homeostasis has been implicated in many
cancers and has recently become a therapeutic and chemosensitization target of interest …

The advent of immunotherapy has revolutionized cancer treatments. However, the
application of immune checkpoint inhibitors may entail severe side effects, with the risk of …

Antibody Secreting Cells (ASCs) are a fundamental component of humoral immunity,
however, deregulated or excessive antibody production contributes to the pathology of …

Background Multiple myeloma (MM) is characterized by clonal expansion of malignant
plasma cells in the bone marrow. While recent advances in treatment for MM have improved …

Here, we describe the synthesis and biologic activity evaluation of 20 novel synthetic marine
sponge alkaloid analogues with 2‐amino‐1H‐imidazol (2‐AI) core. Cytotoxicity was tested …

Simple Summary Non-small cell lung cancer (NSCLC) is one of the main causes of cancer-
related deaths worldwide. Intratumoral heterogeneity (ITH) is responsible for the majority of …