The Nrf2 transcription factor governs the expression of hundreds genes involved in cell
defense against oxidative stress, the hallmark of numerous diseases such as …

Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …

Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …

Increased reactive oxygen species production and oxidative stress have been implicated in
the pathogenesis of numerous neurodegenerative conditions including among others …

Significance: Central nervous system (CNS) diseases are disorders of the brain and/or
spinal cord and include neurodegenerative diseases such as Alzheimer's disease …

The brain is very sensitive to changes in redox status; thus maintaining redox homeostasis
in the brain is critical for the prevention of accumulating oxidative damage. Aging is the …

Nrf2 and NF-κB are important regulators of the response to oxidative stress and
inflammation in the body. Previous pharmacological and genetic studies have confirmed …

The nuclear factor erythroid 2 related factor 2 (NRF2) is a key regulator of endogenous
inducible defense systems in the body. Under physiological conditions NRF2 is mainly …

Aims: This preclinical study was aimed at determining whether pharmacological targeting of
transcription factor NRF2, a master controller of many homeostatic genes, might provide a …