Cancer cell lines for drug discovery and development
JL Wilding, WF Bodmer - Cancer research, 2014 - AACR
Despite the millions of dollars spent on target validation and drug optimization in preclinical
models, most therapies still fail in phase III clinical trials. Our current model systems, or the …
models, most therapies still fail in phase III clinical trials. Our current model systems, or the …
The lymph node pre-metastatic niche
JP Sleeman - Journal of molecular medicine, 2015 - Springer
Lymph node metastases occur frequently during the progression of many types of cancer,
and their presence often reflects poor prognosis. The drainage of tumor-derived factors such …
and their presence often reflects poor prognosis. The drainage of tumor-derived factors such …
Exosomes derived from human primary and metastatic colorectal cancer cells contribute to functional heterogeneity of activated fibroblasts by reprogramming their …
Cancer‐associated fibroblasts (CAFs) are a heterogeneous population of activated
fibroblasts that constitute a dominant cellular component of the tumor microenvironment …
fibroblasts that constitute a dominant cellular component of the tumor microenvironment …
A randomised, double blind, placebo-controlled pilot study of oral artesunate therapy for colorectal cancer
Background Artesunate is an antimalarial agent with broad anti-cancer activity in in vitro and
animal experiments and case reports. Artesunate has not been studied in rigorous clinical …
animal experiments and case reports. Artesunate has not been studied in rigorous clinical …
Association of IL-36γ with tertiary lymphoid structures and inflammatory immune infiltrates in human colorectal cancer
AM Weinstein, NA Giraldo, F Petitprez, C Julie… - Cancer Immunology …, 2019 - Springer
IL-1 family cytokines play a dual role in the gut, with different family members contributing
either protective or pathogenic effects. IL-36γ is an IL-1 family cytokine involved in polarizing …
either protective or pathogenic effects. IL-36γ is an IL-1 family cytokine involved in polarizing …
Myofibroblasts are distinguished from activated skin fibroblasts by the expression of AOC3 and other associated markers
L Hsia, N Ashley, D Ouaret, LM Wang… - Proceedings of the …, 2016 - National Acad Sciences
Pericryptal myofibroblasts in the colon and rectum play an important role in regulating the
normal colorectal stem cell niche and facilitating tumor progression. Myofibroblasts …
normal colorectal stem cell niche and facilitating tumor progression. Myofibroblasts …
Cancer-associated fibroblast heterogeneity and its influence on the extracellular matrix and the tumor microenvironment
K Knipper, SI Lyu, A Quaas, CJ Bruns… - International Journal of …, 2023 - mdpi.com
The tumor microenvironment comprises multiple cell types, like cancer cells, endothelial
cells, fibroblasts, and immune cells. In recent years, there have been massive research …
cells, fibroblasts, and immune cells. In recent years, there have been massive research …
68Ga-FAPI-04 vs. 18F-FDG in a longitudinal preclinical PET imaging of metastatic breast cancer
F Ding, C Huang, C Liang, C Wang, J Liu… - European Journal of …, 2021 - Springer
Purpose This longitudinal study aims to evaluate the performance of 68 Ga-FAPI-04 and 18F-
FDG and to profile the dynamic process of tumor metastasis in a preclinical 4T1 breast …
FDG and to profile the dynamic process of tumor metastasis in a preclinical 4T1 breast …
[HTML][HTML] Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals distinct cancer-associated fibroblasts in head and neck squamous cell carcinoma
Q Zhang, Y Wang, C Xia, L Ding, Y Pu… - Annals of …, 2021 - ncbi.nlm.nih.gov
Background The heterogeneity of cancer-associated fibroblasts (CAFs) in head and neck
squamous cell carcinoma (HNSCC) has been widely acknowledged, but has not yet been …
squamous cell carcinoma (HNSCC) has been widely acknowledged, but has not yet been …
[HTML][HTML] Altered expression of fibroblast activation protein-α (FAP) in colorectal adenoma-carcinoma sequence and in lymph node and liver metastases
JD Solano-Iturri, M Beitia, P Errarte… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is a major health problem in elderly people because of its high
incidence and high mortality rate. Despite early screening programs, more than half of CRC …
incidence and high mortality rate. Despite early screening programs, more than half of CRC …