The phospholipid cardiolipin (CL) is an essential constituent of mitochondrial membranes
and plays a role in many mitochondrial processes, including respiration and energy …

Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

Aldehyde dehydrogenases (ALDHs) belong to a superfamily of enzymes that play a key role
in the metabolism of aldehydes of both endogenous and exogenous derivation. The human …

A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a
subject of recent interest, as its role in detoxifying aldehydes that accumulate through …

Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases,
including multiple cardiovascular disorders. However, translation of ROS scavengers …

Numerous conditions promote oxidative stress, leading to the build-up of reactive aldehydes
that cause cell damage and contribute to cardiac diseases. Aldehyde dehydrogenases …

While ethanol intake at high levels (3–4 or more drinks), either in acute (occasional binge
drinking) or chronic (daily) settings, increases the risk for myocardial infarction and stroke …

Aims We previously demonstrated that pharmacological activation of mitochondrial
aldehyde dehydrogenase 2 (ALDH2) protects the heart against acute ischaemia/reperfusion …

Smoking, heavy alcohol drinking and drug abuse are detrimental lifestyle factors leading to
loss of million years of healthy life annually. One of the major health complications caused …

Aldehyde dehydrogenase 2 (ALDH2) has both dehydrogenase and esterase activity; its
dehydrogenase activity is closely related to the metabolism of aldehydes produced under …