This Review explores the dynamic behavior of water within nanopores and biological
channels in lipid bilayer membranes. We focus on molecular simulation studies, alongside …

Proton channels exist in a wide variety of membrane proteins where they transport protons
rapidly and efficiently. Usually the proton pathway is formed mainly by water molecules …

1. Introduction 172. Dynamics of many-body systems 192.1 Effective dynamics of reduced
systems 212.2 The constraint of thermodynamic equilibrium 242.3 Mean-field theories 253 …

Computer simulation methods are becoming increasingly widespread as tools for studying
the structure and dynamics of lipid bilayer membranes. The length scale and time scale …

How does the brain work? After a century of research, we still lack a coherent view of how
neurons process signals and control our activities. But as the field of computational …

The M2 protein of influenza A viruses forms a tetrameric pH-activated proton-selective
channel that is targeted by the amantadine class of antiviral drugs. Its ion channel function …

The transmembrane domain of the M2 protein from influenza A virus forms a nearly uniform
and ideal helix in a liquid crystalline bilayer environment. The exposure of the hydrophilic …

An interhelical distance has been precisely measured by REDOR solid-state NMR
spectroscopy in the transmembrane tetrameric bundle of M2-TMP, from the M2 proton …

The mechanosensitive channel of large conductance (MscL) in prokaryotes plays a crucial
role in exocytosis as well as in the response to osmotic downshock. The channel can be …

The M2 proton channel from the influenza A virus is a small protein with a single
transmembrane helix that associates to form a tetramer in vivo. This protein forms proton …