This Review discusses the major advances and changes made over the past 3 years to our
understanding of chimeric antigen receptor (CAR) T cell efficacy and safety. Recently, the …

Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in
immune activation against abnormal cells. Different from events required for T cell activation …

Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …

Antibody-dependent cellular cytotoxicity (ADCC) is a key effector mechanism of natural killer
(NK) cells that is mediated by therapeutic monoclonal antibodies (mAbs). This process is …

During the past decades, anticancer immunotherapy has evolved from a promising
therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now …

Natural killer (NK) cells can induce an antigen-independent immune response against
malignant cells. A growing number of scientific reports and clinical studies have shown …

Natural killer (NK) cells play critical roles in host immunity against cancer. In response,
cancers develop mechanisms to escape NK cell attack or induce defective NK cells. Current …

Adoptive cell therapy has emerged as a powerful treatment for advanced cancers resistant
to conventional agents. Most notable are the remarkable responses seen in patients …

By fusing the extracellular domain of the natural killer (NK) cell receptor NKG2D to DAP12,
we constructed a chimeric antigen receptor (CAR) to improve NK cell tumor responses. An …

NK cells have therapeutic potential for a wide variety of human malignancies. However,
because NK cells expand poorly in vitro, have limited life spans in viv o, and represent a …