NLRP3 inflammasome-targeting nanomicelles for preventing ischemia–reperfusion-induced inflammatory injury

R Prakash, A Vyawahare, R Sakla, N Kumari… - ACS …, 2023 - ACS Publications
Ischemia–reperfusion (I/R) injury is a disease process that affects several vital organs. There
is widespread agreement that the NLRP3 inflammasome pathway plays a crucial role in the …

N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye

P Deshpande, AV Chimata, E Snider, A Singh… - Cell Death & …, 2023 - nature.com
Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, manifests as
accumulation of amyloid-beta-42 (Aβ42) plaques and intracellular accumulation of …

Antioxidant, antimetastatic and apoptotic potential of silver nanoparticles synthesized by leaf and callus extracts of Hyptis suaveolens L.

S Botcha, SD Prattipati - South African Journal of Botany, 2023 - Elsevier
Green synthesis of silver nanoparticles using plant extracts as reducing agents is an
environmental friendly and cost-effective approach. This study aims to provide a detailed …

Quantifying innervation facilitated by deep learning in wound healing

AS Mehta, S Teymoori, C Recendez, D Fregoso… - Scientific Reports, 2023 - nature.com
The peripheral nerves (PNs) innervate the dermis and epidermis, and are suggested to play
an important role in wound healing. Several methods to quantify skin innervation during …

Exploring the role of N-acetyltransferases in diseases: a focus on N-acetyltransferase 9 in neurodegeneration

P Deshpande, AV Chimata, A Singh - Neural Regeneration …, 2025 - journals.lww.com
Acetyltransferases, required to transfer an acetyl group on protein are highly conserved
proteins that play a crucial role in development and disease. Protein acetylation is a …

Exploring advanced Drosophila cell death techniques and cancer-related studies

D Tendero-Lopez, M Dominguez, ML Uribe - Frontiers in Cell Death, 2024 - frontiersin.org
Cell death is an essential physiological process for the survival of multicellular organisms.
Our understanding of programmed cell death in development, immune function …

miR-277 targets the proapoptotic gene-hid to ameliorate Aβ42-mediated neurodegeneration in Alzheimer's model

P Deshpande, CY Chen, AV Chimata, JC Li… - Cell Death & …, 2024 - nature.com
Abstract Alzheimer's disease (AD), an age-related progressive neurodegenerative disorder,
exhibits reduced cognitive function with no cure to date. One of the reasons for AD is the …

Targeting the HECTD3-p62 axis increases the radiosensitivity of triple negative breast cancer cells

M Huang, W Liu, Z Cheng, F Li, Y Kong, C Yang… - Cell Death …, 2024 - nature.com
Triple negative breast cancer is the most malignant subtype of breast cancer and current
treatment options are limited. Radiotherapy is one of the primary therapeutic options for …

A cell atlas of the larval Aedes aegypti ventral nerve cord

C Yin, T Morita, JZ Parrish - Neural Development, 2024 - Springer
Mosquito-borne diseases account for nearly 1 million human deaths annually, yet we have a
limited understanding of developmental events that influence host-seeking behavior and …

Transcriptional pausing factor M1BP regulates cellular homeostasis by suppressing autophagy and apoptosis in Drosophila eye

AV Chimata, H Darnell, A Raj, M Kango-Singh… - Autophagy …, 2023 - Taylor & Francis
During organogenesis cellular homeostasis plays a crucial role in patterning and growth.
The role of promoter proximal pausing of RNA polymerase II, which regulates transcription of …