Hypoxia-inducible factors (HIFs) are broadly expressed in human cancers, and HIF1α and
HIF2α were previously suspected to promote tumour progression through largely …

MicroRNAs (miRNAs) are a class of short non-coding RNAs that bind mRNAs through partial
base-pair complementarity with their target genes, resulting in post-transcriptional …

Abstract The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …

Signaling pathway alterations are important in the development of gastric cancer (GC).
Deregulation of the PI3K/AKT/mTOR pathway plays a crucial role in the regulation of …

The endothelium plays a pivotal role in maintaining vascular health. Obesity is a global
epidemic that has seen dramatic increases in both adult and pediatric populations. Obesity …

Among the molecular, biochemical and cellular processes that orchestrate the development
of the different phenotypes of cardiac hypertrophy in response to physiological stimuli or …

Multiple myeloma (MM) cells induce relevant angiogenic effects within the human bone
marrow milieu (huBMM) by the aberrant expression of angiogenic factors. Hypoxia triggers …

MicroRNAs (miRNAs) are small non-coding RNA molecules that negatively regulate gene
expression of their targets at the post-transcriptional levels. A single miRNA can target up to …

Activation of the PI3K/AKT pathway, a common mechanism in all subtypes of endometrial
cancers (endometrioid and non-endometrioid tumors), has important roles in contributing to …

MicroRNA (miRNA) influences carcinogenesis at multiple stages and it can effectively
control tumor radiosensitivity by affecting DNA damage repair, cell cycle checkpoint …