Voltage-gated calcium channels in nonexcitable tissues
The identification of a gain-of-function mutation in CACNA1C as the cause of Timothy
syndrome, a rare disorder characterized by cardiac arrhythmias and syndactyly, highlighted …
syndrome, a rare disorder characterized by cardiac arrhythmias and syndactyly, highlighted …
Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin
Mechanical forces are fundamental regulators of cell behaviors. However, molecular
regulation of mechanotransduction remain poorly understood. Here, we identified the …
regulation of mechanotransduction remain poorly understood. Here, we identified the …
STING suppresses bone cancer pain via immune and neuronal modulation
Patients with advanced stage cancers frequently suffer from severe pain as a result of bone
metastasis and bone destruction, for which there is no efficacious treatment. Here, using …
metastasis and bone destruction, for which there is no efficacious treatment. Here, using …
[HTML][HTML] Bone metabolism regulation: Implications for the treatment of bone diseases
D Yao, L Huang, J Ke, M Zhang, Q Xiao… - Biomedicine & …, 2020 - Elsevier
Bone cells in the human body are continuously engaged in cellular metabolism, including
the interaction between bone cells, the interaction between the erythropoietic cells of the …
the interaction between bone cells, the interaction between the erythropoietic cells of the …
Low-intensity pulsed ultrasound/nanomechanical force generators enhance osteogenesis of BMSCs through microfilaments and TRPM7
H Yao, L Zhang, S Yan, Y He, H Zhu, Y Li… - Journal of …, 2022 - Springer
Background Low-intensity pulsed ultrasound (LIPUS) has been reported to accelerate
fracture healing, but the mechanism is unclear and its efficacy needs to be further optimized …
fracture healing, but the mechanism is unclear and its efficacy needs to be further optimized …
L-type voltage-gated Ca2+ channel CaV1.2 regulates chondrogenesis during limb development
All cells, including nonexcitable cells, maintain a discrete transmembrane potential (V mem),
and have the capacity to modulate V mem and respond to their own and neighbors' changes …
and have the capacity to modulate V mem and respond to their own and neighbors' changes …
Chronic exposure to environmentally relevant concentration of fluoride impairs osteoblast's collagen synthesis and matrix mineralization: Involvement of epigenetic …
Globally, 200 million people are suffering from toxic manifestations of Fluoride (F), dental
and skeletal fluorosis; unfortunately, there is no treatment. To unravel the pathogenesis of …
and skeletal fluorosis; unfortunately, there is no treatment. To unravel the pathogenesis of …
[HTML][HTML] Increased Ca2+ influx through CaV1. 2 drives aortic valve calcification
M Matsui, R Bouchareb, M Storto, Y Hussain, A Gregg… - JCI insight, 2022 - ncbi.nlm.nih.gov
Calcific aortic valve disease (CAVD) is heritable, as revealed by recent GWAS. While
polymorphisms linked to increased expression of CACNA1C—encoding the Ca V 1.2 L-type …
polymorphisms linked to increased expression of CACNA1C—encoding the Ca V 1.2 L-type …
Osteogenesis imperfecta mutations in plastin 3 lead to impaired calcium regulation of actin bundling
Mutations in actin-bundling protein plastin 3 (PLS3) emerged as a cause of congenital
osteoporosis, but neither the role of PLS3 in bone development nor the mechanisms …
osteoporosis, but neither the role of PLS3 in bone development nor the mechanisms …
Fabrication of chondroitin sulfate calcium complex and its chondrocyte proliferation in vitro
Q Shen, C Zhang, H Mo, H Zhang, X Qin, J Li… - Carbohydrate …, 2021 - Elsevier
Chondroitin sulfate (CS)-calcium complex (CSCa) was fabricated, and the structural
characteristics of CSCa and its proliferative bioactivity to the chondrocyte were investigated …
characteristics of CSCa and its proliferative bioactivity to the chondrocyte were investigated …