Synopsis Atorvastatin is a synthetic HMG-CoA reductase inhibitor which lowers plasma
cholesterol levels by inhibiting endogenous cholesterol synthesis. It also reduces …

This article reviews the pharmacokinetic properties of HMG-CoA reductase inhibitors (or
statins), as reported in humans. Most data presented here refer to commercially available …

The pharmacodynamic effects and pharmacokinetics of atorvastatin, a potent investigational
inhibitor of HMG‐CoA reductase, were studied in 16 normolipidemic subjects after …

Atorvastatin is a new 3‐hydroxy‐3‐methylglutaryl‐coenzyme A (HMG‐CoA) reductase
inhibitor that reduces plasma cholesterol by inhibiting cholesterol synthesis and increasing …

Atorvastatin (AT) is a second-generation potent inhibitor of 3-hydroxy-3-methylglutaryl-CoA
reductase, clinically approved for lowering plasma cholesterol. Using a mixture of [D5/D0] …

To determine whether atorvastatin, a new HMG‐CoA reductase inhibitor, could be
administered with food in Phase II and III clinical trials, a nonblind, randomized, two‐way …

The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, interactions, and
formulary considerations of atorvastatin relative to other hydroxymethylglutaryl-coenzyme A …

Atorvastatin calcium is an HMG‐coenzyme A (CoA) reductase inhibitor that was approved by
the Food and Drug Administration on December 17, 1996. Like other such agents, it inhibits …

About ten years ago, grapefruit juice was observed to increase the plasma concentrations
and effects of felodipine. Since then, grapefruit juice has been found to interact with more …