Abstract “Functional wasteland,”“Nonrecombining desert,” and “Gene-poor chromosome”
are only some examples of the different definitions given to the Y chromosome in the last …

Turner syndrome was one of the first human genetic disorders ascribed to haploinsufficiency
but the identification of specific genes responsible for the phenotype has been problematic …

Growth retardation resulting in short stature is a major concern for parents and due to its
great variety of causes, a complex diagnostic challenge for clinicians. A major locus involved …

DFFRY (the Y-linked homologue of the DFFRX Drosophila fat-facets related X gene) maps
to proximal Yq11. 2 within the interval defining the AZFa spermatogenic phenotype. The …

BACKGROUND Turner syndrome is characterised by a 45, X karyotype and a variety of
skeletal, lymphoedemic, and gonadal anomalies. Genes involved in the Turner phenotype …

The human Y chromosome contains over 60 million nucleotides, but least number of genes
compared to any other chromosome and acts as a genetic determinant of the male …

Although most of the human Y does not normally recombine with the X chromosome, there
are two limited regions of sequence identity with the X that permit pairing and recombination …

Isodicentric chromosome formation is the most common structural abnormality of the Y
chromosome. As dicentrics are mitotically unstable, they are subsequently lost during cell …

Recent genome analysis of the Y chromosome has increased the number of genes found on
this chromosome markedly. Many of these genes in the part of the Y chromosome that does …

It is estimated that about 30 to 40% of couples seeking fertility treatments are diagnosed with
male factor infertility. These males have a range of gonadal dysfunctions which include …