The effective delivery of drugs to the eye remains a challenge. The eye has a myriad of
defense systems and physiological barriers that leaves ocular drug delivery systems with …

Spinal cord injury (SCI) is an injurious process that begins with immediate physical damage
to the spinal cord and associated tissues during an acute traumatic event. However, the …

Type 2 diabetes mellitus (T2DM) is a major chronic disease that is prevalent worldwide, and
it is characterized by an increase in blood glucose, disturbances in the metabolism, and …

The blood-brain barrier (BBB) is a physiological regulator of transport of essential items from
blood to brain for the maintenance of homeostasis of the central nervous system (CNS) …

One of the main obstacles in the treatment of neurological diseases, perhaps the biggest
one, is the delivery of therapeutic compounds to the central nervous system, and …

Abstract Neprilysin (NPL), the rate-limiting enzyme for amyloid beta peptide (AβP), appears
to play a crucial role in the pathogenesis of Alzheimer's disease (AD). Since mesenchymal …

Military personnel are often subjected to sleep deprivation (SD) during combat operations.
Since SD is a severe stress and alters neurochemical metabolism in the brain, a possibility …

Abstract DL-3-n-butylphthalide (DL-NBP) is one of the constituents of Chinese celery extract
that is used to treat stroke, dementia, and ischemic diseases. However, its role in traumatic …

Spinal cord injury (SCI) is a distressing injury and an irretrievable dramatic event that can
debilitate victims for lifespan. Recovery and treatment of SCI is critical challenges for …

Alzheimer's disease (AD) is estimated to be afflicting over 55 millions of individual worldwide
in 2018–19 for which no suitable clinical therapeutic measures have been developed so far …