The mechanics of microtubule networks in cell division
The primary goal of a dividing somatic cell is to accurately and equally segregate its genome
into two new daughter cells. In eukaryotes, this process is performed by a self-organized …
into two new daughter cells. In eukaryotes, this process is performed by a self-organized …
The nuclear mitotic apparatus (NuMA) protein: A key player for nuclear formation, spindle assembly, and spindle positioning
T Kiyomitsu, S Boerner - Frontiers in cell and developmental biology, 2021 - frontiersin.org
The nuclear mitotic apparatus (NuMA) protein is well conserved in vertebrates, and
dynamically changes its subcellular localization from the interphase nucleus to the …
dynamically changes its subcellular localization from the interphase nucleus to the …
[HTML][HTML] Developmental defects in Huntington's disease show that axonal growth and microtubule reorganization require NUMA1
M Capizzi, R Carpentier, E Denarier, A Adrait… - Neuron, 2022 - cell.com
Although the classic symptoms of Huntington's disease (HD) manifest in adulthood, neural
progenitor cell behavior is already abnormal by 13 weeks' gestation. To determine how …
progenitor cell behavior is already abnormal by 13 weeks' gestation. To determine how …
Measuring pushing and braking forces generated by ensembles of kinesin-5 crosslinking two microtubules
The proper organization of the microtubule-based mitotic spindle is proposed to depend on
nanometer-sized motor proteins generating forces that scale with a micron-sized geometric …
nanometer-sized motor proteins generating forces that scale with a micron-sized geometric …
Confined-microtubule assembly shapes three-dimensional cell wall structures in xylem vessels
Properly patterned deposition of cell wall polymers is prerequisite for the morphogenesis of
plant cells. A cortical microtubule array guides the two-dimensional pattern of cell wall …
plant cells. A cortical microtubule array guides the two-dimensional pattern of cell wall …
Protein diffusion along Protein and DNA lattices: role of electrostatics and disordered regions
Diffusion is a pervasive process present in a broad spectrum of cellular reactions. Its
mathematical description has existed for nearly two centuries and permits the construction of …
mathematical description has existed for nearly two centuries and permits the construction of …
NuMA recruits dynein activity to microtubule minus-ends at mitosis
To build the spindle at mitosis, motors exert spatially regulated forces on microtubules. We
know that dynein pulls on mammalian spindle microtubule minus-ends, and this localized …
know that dynein pulls on mammalian spindle microtubule minus-ends, and this localized …
[HTML][HTML] Diffusible crosslinkers generate directed forces in microtubule networks
Cytoskeletal remodeling is essential to eukaryotic cell division and morphogenesis. The
mechanical forces driving the restructuring are attributed to the action of molecular motors …
mechanical forces driving the restructuring are attributed to the action of molecular motors …
Solid friction between soft filaments
Any macroscopic deformation of a filamentous bundle is necessarily accompanied by local
sliding and/or stretching of the constituent filaments,. Yet the nature of the sliding friction …
sliding and/or stretching of the constituent filaments,. Yet the nature of the sliding friction …
Mutations in human tubulin proximal to the kinesin-binding site alter dynamic instability at microtubule plus-and minus-ends
The assembly of microtubule-based cellular structures depends on regulated tubulin
polymerization and directional transport. Here, we purify and characterize tubulin …
polymerization and directional transport. Here, we purify and characterize tubulin …