Highlights•Copper and iron play key roles in the virulence of Cryptococcus
neoformans.•Metals influence the cell wall, melanin formation, and capsule elaboration.•The …

Fungal pathogens destroy our crops and cause hazardous human infections, therefore
threatening our health and food security. The ability of fungal pathogens to sense and …

Candida albicans is among the most significant human fungal pathogens. However, the vast
majority of C. albicans studies have focused on a single clinical isolate and its marked …

Iron acquisition is critical for pathogenic fungi to adapt to and survive within the host
environment. However, to same extent, the fungi must also avoid the detrimental effects …

Mitochondrial functions are critical for the ability of the fungal pathogen Cryptococcus
neoformans to cause disease. However, mechanistic connections between key functions …

Ferritin, a major iron storage protein in vertebrates, supplies iron upon iron deficiency.
Ferritin is also found extracellularly, and acts as an iron carrier and a contributor to the …

Fungal pathogens cause life-threatening diseases in humans, and the increasing
prevalence of these diseases emphasizes the need for new targets for therapeutic …

Agaricus bisporus secretes siderophore to uptake environmental iron. Siderophore
secretion in A. bisporus was enabled only in the iron-free minimal medium due to iron …

ABSTRACT Flucytosine (5-FC) is an antifungal agent commonly used for treatment of
cryptococcosis and several other systemic mycoses. In fungi, cytosine permease and …

Vacuoles are dynamic cellular organelles, and their morphology is altered by various stimuli
or stresses. Vacuoles play an important role in the physiology and virulence of many fungal …