Triple-negative breast cancer: a brief review about epidemiology, risk factors, signaling pathways, treatment and role of artificial intelligence

NM Almansour - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Triple-negative breast cancer (TNBC) is a kind of breast cancer that lacks estrogen,
progesterone, and human epidermal growth factor receptor 2. This cancer is responsible for …

Newly developed targeted therapies against the androgen receptor in triple-negative breast cancer: A review

E Choupani, MM Gomari, S Zanganeh, S Nasseri… - Pharmacological …, 2023 - Elsevier
Among different types of breast cancers (BC), triple-negative BC (TNBC) amounts to 15% to
20% of breast malignancies. Three principal characteristics of TNBC cells are (i) extreme …

The impact of site-specific digital histology signatures on deep learning model accuracy and bias

FM Howard, J Dolezal, S Kochanny, J Schulte… - Nature …, 2021 - nature.com
Abstract The Cancer Genome Atlas (TCGA) is one of the largest biorepositories of digital
histology. Deep learning (DL) models have been trained on TCGA to predict numerous …

Clinicopathologic characteristics and prognosis of ERBB2-low breast cancer among patients in the National Cancer Database

DS Peiffer, F Zhao, N Chen, OM Hahn, R Nanda… - JAMA …, 2023 - jamanetwork.com
Importance Given conflicting results regarding the prognosis of erb-b2 receptor tyrosine
kinase 2 (ERBB2; formerly HER2 or HER2/neu)–low breast cancer, a large-scale, nationally …

Immunotherapy for metastatic triple negative breast cancer: current paradigm and future approaches

V Geurts, M Kok - Current Treatment Options in Oncology, 2023 - Springer
Opinion statement In approximately 15–20% of the patients diagnosed with breast cancer, it
comprises the triple negative (TN) subtype, which until recently lacked targets for specific …

Disparities in breast cancer

VF Grabinski, OW Brawley - Obstetrics and Gynecology …, 2022 - obgyn.theclinics.com
In the western world, breast cancer is the most common lethal cancer in women and the
second leading cause of cancer death behind lung cancer. 1 The American Cancer Society …

Triple negative breast cancer: Immunogenicity, tumor microenvironment, and immunotherapy

S Loizides, A Constantinidou - Frontiers in genetics, 2023 - frontiersin.org
Triple negative breast cancer (TNBC) is a biologically diverse subtype of breast cancer
characterized by genomic and transcriptional heterogeneity and exhibiting aggressive …

Clinical trials of immunotherapy in triple-negative breast cancer

FM Howard, AT Pearson, R Nanda - Breast Cancer Research and …, 2022 - Springer
Purpose Immunotherapy has started to transform the treatment of triple-negative breast
cancer (TNBC), in part due to the unique immunogenicity of this breast cancer subtype. This …

Triple-negative breast cancer: epidemiology, molecular mechanisms, and modern vaccine-based treatment strategies

AM Karim, JE Kwon, T Ali, J Jang, I Ullah… - Biochemical …, 2023 - Elsevier
Long-standing scarcity of efficacious treatments and tumor heterogeneity have contributed to
triple-negative breast cancer (TNBC), a subtype with a poor prognosis and aggressive …

Biomimetic multifunctional nanodrugs enable regulating abnormal tumor metabolism and amplifying PDT-induced immunotherapy for synergistically enhanced tumor …

Y Liu, H Wu, S Wang, X Zhang, L Gong, C Xiao, C Liu… - Materials Today, 2023 - Elsevier
Aberrant tumor metabolic activities not only promote the aggressiveness and proliferation of
tumor cells in the harsh microenvironment in vivo, but also contribute to immune cell …