Mitochondria import many hundreds of different proteins that are encoded by nuclear genes.
These proteins are targeted to the mitochondria, translocated through the mitochondrial …

Instability of the mitochondrial genome (mtDNA) is a general problem from yeasts to
humans. However, its genetic control is not well documented except in the yeast …

The mitochondrion is arguably the most complex organelle in the budding yeast cell
cytoplasm. It is essential for viability as well as respiratory growth. Its innermost aqueous …

Mitochondria contain their own genome which codes for a small number of proteins. Most
mitochondrial translation products are part of the membrane-embedded reaction centers of …

Background The mitochondrial respiratory chain produces metabolic energy by oxidative
phosphorylation. Biogenesis of the respiratory chain requires the coordinated expression of …

Abstract F 1 F 0-ATP synthases are multimeric protein complexes and common prerequisites
for their correct assembly are (i) provision of subunits in appropriate relative amounts,(ii) …

Mitochondrial function relies on the activity of oxidative phosphorylation to synthesise ATP
and generate an electrochemical gradient across the inner mitochondrial membrane. These …

Publisher Summary This chapter briefly reviews some recent advances in the areas of the
subunit structure and the different functions of the ATP synthase, but focuses mainly on the …

The Saccharomyces cerevisiae succinate dehydrogenase (SDH) provides an excellent
model system for studying the assembly, structure, and function of a mitochondrial succinate …

The highly streamlined mitochondrial genome encodes almost exclusively a handful of
transmembrane components of the respiratory chain complex. In order to ensure the correct …