How does adenosine control neuronal dysfunction and neurodegeneration?
RA Cunha - Journal of neurochemistry, 2016 - Wiley Online Library
The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …
Cellular distribution and functions of P2 receptor subtypes in different systems
G Burnstock, GE Knight - Int Rev Cytol, 2004 - books.google.com
In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …
Adenosine and brain function
BB Fredholm, JF Chen, RA Cunha… - Int Rev …, 2005 - books.google.com
A. Cellular and Subcellular Localization B. Pharmacological Tools to Study Adenosine
Receptors C. Signaling Via Adenosine Receptors D. Regulation of Receptor Expression and …
Receptors C. Signaling Via Adenosine Receptors D. Regulation of Receptor Expression and …
ATP as a multi-target danger signal in the brain
ATP is released in an activity-dependent manner from different cell types in the brain,
fulfilling different roles as a neurotransmitter, neuromodulator, in astrocyte-to-neuron …
fulfilling different roles as a neurotransmitter, neuromodulator, in astrocyte-to-neuron …
Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors
RA Cunha - Neurochemistry international, 2001 - Elsevier
Adenosine exerts two parallel modulatory roles in the CNS, acting as a homeostatic
modulator and also as a neuromodulator at the synaptic level. We will present evidence to …
modulator and also as a neuromodulator at the synaptic level. We will present evidence to …
Neuroprotection by adenosine in the brain: From A1 receptor activation to A2A receptor blockade
RA Cunha - Purinergic signalling, 2005 - Springer
Adenosine is a neuromodulator that operates via the most abundant inhibitory adenosine A
1 receptors (A 1 Rs) and the less abundant, but widespread, facilitatory A 2A Rs. It is …
1 receptors (A 1 Rs) and the less abundant, but widespread, facilitatory A 2A Rs. It is …
Adenosine receptors in the nervous system: pathophysiological implications
JA Ribeiro, AM Sebastiao, A De Mendonça - Progress in neurobiology, 2002 - Elsevier
Adenosine is a ubiquitous homeostatic substance released from most cells, including
neurones and glia. Once in the extracellular space, adenosine modifies cell functioning by …
neurones and glia. Once in the extracellular space, adenosine modifies cell functioning by …
[HTML][HTML] Synaptic and memory dysfunction in a β-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine
Abstract Adenosine A 2A receptors (A 2A R) overfunction causes synaptic and memory
dysfunction in early Alzheimer's disease (AD). In a β-amyloid (Aβ 1-42)-based model of early …
dysfunction in early Alzheimer's disease (AD). In a β-amyloid (Aβ 1-42)-based model of early …
Adenosine receptors and the central nervous system
AM Sebastiao, JA Ribeiro - Adenosine receptors in health and disease, 2009 - Springer
The adenosine receptors (ARs) in the nervous system act as a kind of “go-between” to
regulate the release of neurotransmitters (this includes all known neurotransmitters) and the …
regulate the release of neurotransmitters (this includes all known neurotransmitters) and the …
Adenosine in the spinal cord and periphery: release and regulation of pain
J Sawynok, XJ Liu - Progress in neurobiology, 2003 - Elsevier
In the central nervous system (CNS), adenosine is an important neuromodulator and
regulates neuronal and non-neuronal cellular function (eg microglia) by actions on …
regulates neuronal and non-neuronal cellular function (eg microglia) by actions on …