The cilium, once considered a vestigial structure, is a conserved, microtubule-based
organelle critical for transducing extracellular chemical and mechanical signals that control …

As motile organelles and sensors, cilia play pivotal roles in cell physiology, development
and organ homeostasis. Ciliary defects are associated with a class of cilia-related diseases …

Cilia are essential organelles that protrude from the cell body. Cilia are made of a
microtubule-based structure called the axoneme. In most types of cilia, the ciliary tip is …

Mucociliary clearance, the physiological process by which mammalian conducting airways
expel pathogens and unwanted surface materials from the respiratory tract, depends on the …

The primary cilium is a conserved microtubule-based organelle that is critical for transducing
developmental, sensory and homeostatic signaling pathways. It comprises an axoneme with …

The ciliary transition zone (TZ) is a complex structure found at the cilia base. Defects in TZ
assembly are associated with human ciliopathies. In most eukaryotes, three protein …

The microtubule (MT) plus-end tracking protein EB1 is present at the tips of cilia and flagella;
end-binding protein 1 (EB1) remains at the tip during flagellar shortening and in the absence …

Primary cilia, microtubule‐based protrusions present on the surface of most mammalian
cells, function as sensory organelles that monitor extracellular signals and transduce them …

With eight flagella of four different lengths, the parasitic protist Giardia is an ideal model to
evaluate flagellar assembly and length regulation. To determine how four different flagellar …

Short-rib polydactyly syndromes (SRPS) and Asphyxiating thoracic dystrophy (ATD) or
Jeune Syndrome are recessively inherited skeletal ciliopathies characterized by profound …