Cellulose is the most abundant renewable natural biological resource, and the production of
biobased products and bioenergy from less costly renewable lignocellulosic materials is …

Synthetic biologists engineer complex artificial biological systems to investigate natural
biological phenomena and for a variety of applications. We outline the basic features of …

Synthetic biologists come in two broad classes. One uses unnatural molecules to reproduce
emergent behaviours from natural biology, with the goal of creating artificial life. The other …

This introductory textbook covers all aspects of catalysis. It also bridges computational
methods, industrial applications and green chemistry, with over 600 references. The book is …

Many research groups successfully rely on whole-gene random mutagenesis and
recombination approaches for the directed evolution of enzymes. Recent advances in …

Protein design allows sequence-to-structure relationships in proteins to be examined and,
potentially, new protein structures and functions to be made to order. To succeed, however …

Modern enzyme development relies to an increasing extent on strategies based on diversity
generation followed by screening for variants with optimised properties. In principle, these …

The creation of novel enzymes capable of catalyzing any desired chemical reaction is a
grand challenge for computational protein design. Here we describe two new algorithms for …

Antibodies are used extensively in diagnostics and as therapeutic agents. Achieving high-
affinity binding is important for expanding detection limits, extending dissociation half-times …

Improvement in intrinsic enzymatic features is in many instances a prerequisite for the
scalable applicability of many industrially important biocatalysts. To this end, various …