New avenues for the treatment of Huntington's disease
A Kim, K Lalonde, A Truesdell, P Gomes Welter… - International journal of …, 2021 - mdpi.com
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG expansion in
the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum …
the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum …
SIRT1 and SIRT2 activity control in neurodegenerative diseases
Sirtuins are NAD+ dependent histone deacetylases (HDAC) that play a pivotal role in
neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They …
neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They …
Molecular mechanisms and potential therapeutical targets in Huntington's disease
C Zuccato, M Valenza, E Cattaneo - Physiological reviews, 2010 - journals.physiology.org
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …
Mitochondrial diseases of the brain
RK Chaturvedi, MF Beal - Free Radical Biology and Medicine, 2013 - Elsevier
Neurodegenerative disorders are debilitating diseases of the brain, characterized by
behavioral, motor and cognitive impairments. Ample evidence underpins mitochondrial …
behavioral, motor and cognitive impairments. Ample evidence underpins mitochondrial …
Calcium dysregulation and homeostasis of neural calcium in the molecular mechanisms of neurodegenerative diseases provide multiple targets for neuroprotection
G Zündorf, G Reiser - Antioxidants & redox signaling, 2011 - liebertpub.com
The intracellular free calcium concentration subserves complex signaling roles in brain.
Calcium cations (Ca2+) regulate neuronal plasticity underlying learning and memory and …
Calcium cations (Ca2+) regulate neuronal plasticity underlying learning and memory and …
Role of manganese in neurodegenerative diseases
Manganese (Mn) is an essential ubiquitous trace element that is required for normal growth,
development and cellular homeostasis. Exposure to high Mn levels causes a clinical …
development and cellular homeostasis. Exposure to high Mn levels causes a clinical …
Therapeutic application of histone deacetylase inhibitors for central nervous system disorders
AG Kazantsev, LM Thompson - Nature reviews Drug discovery, 2008 - nature.com
Histone deacetylases (HDACs)—enzymes that affect the acetylation status of histones and
other important cellular proteins—have been recognized as potentially useful therapeutic …
other important cellular proteins—have been recognized as potentially useful therapeutic …
Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function
LA Raymond, VM André, C Cepeda, CM Gladding… - Neuroscience, 2011 - Elsevier
Huntington's disease (HD) is a progressive, fatal neurological condition caused by an
expansion of CAG (glutamine) repeats in the coding region of the Huntington gene. To date …
expansion of CAG (glutamine) repeats in the coding region of the Huntington gene. To date …
Mechanisms of neurodegeneration in Huntington's disease
Huntington's disease (HD) is caused by an expansion of cytosine–adenine–guanine (CAG)
repeats in the huntingtin gene, which leads to neuronal loss in the striatum and cortex and to …
repeats in the huntingtin gene, which leads to neuronal loss in the striatum and cortex and to …
N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking
AL Orr, S Li, CE Wang, H Li, J Wang… - Journal of …, 2008 - Soc Neuroscience
Huntington's disease (HD) is caused by polyglutamine (polyQ) expansion in huntingtin (htt),
a large (350 kDa) protein that localizes predominantly to the cytoplasm. Proteolytic cleavage …
a large (350 kDa) protein that localizes predominantly to the cytoplasm. Proteolytic cleavage …