Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of
pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability …

DNA damage tolerance and mutagenesis are hallmarks and enabling characteristics of
neoplastic cells that drive tumorigenesis and allow cancer cells to resist therapy. The 'Y …

Nucleolar function and the cellular response to DNA damage have long been studied as
distinct disciplines. New research and a new appreciation for proteins holding multiple …

The nucleolus represents a highly multifunctional intranuclear organelle in which, in addition
to the canonical ribosome assembly, numerous processes such as transcription, DNA repair …

Mutagenesis is a key hallmark and enabling characteristic of cancer cells, yet the diverse
underlying mutagenic mechanisms that shape cancer genomes are not understood. This …

Nucleophosmin (NPM1) is a mostly nucleolar protein with crucial functions in cell growth
and homeostasis, including regulation of ribosome biogenesis and stress response. Such …

Mutations in NPM1, also known as nucleophosmin-1, B23, NO38, or numatrin, are seen in
approximately one-third of patients with acute myeloid leukaemia (AML). A plethora of …

Nucleophosmin is a highly and ubiquitously expressed protein, mainly localized in nucleoli
but able to shuttle between nucleus and cytoplasm. Nucleophosmin plays crucial roles in …

Nucleophosmin (NPM1) is a mainly nucleolar protein that shuttles between nucleoli,
nucleoplasm and cytoplasm to fulfill its many functions. It is a chaperone of both nucleic …

Although large amounts of genomic data are available, it remains a challenge to reliably
infer causal (ie, regulatory) relationships among molecular phenotypes (such as gene …