This tutorial review examines recent developments involving use of Copper-catalyzed Azide-
Alkyne [3+ 2] Cycloaddition (CuAAC) reactions in the synthesis, modification, and …

Head-to-tail cyclic peptides have been reported to bind to multiple, unrelated classesof
receptor with high affinity. They may therefore be considered to beprivileged structures. This …

Brain tumors are highly angiogenesis dependent. The cell adhesion receptor integrin αvβ3
is overexpressed in glioma and activated endothelial cells and plays an important role in …

Integrins are heterodimeric transmembrane proteins able to connect cells with the micro‐
environment. They represent a family of receptors involved in almost all the hallmarks of …

Starting from the first crystal structure of the extracellular segment of the αvβ3 integrin
receptor with a cyclic RGD ligand bound to the active site, structural models for the …

The outstanding physio-pathological role played by integrin receptors in living subjects
motivates the enormous interest shown by scientists worldwide for this topic. More than …

Integrin αvβ3 is an adhesion molecule involved in physiological and pathological
angiogenesis as well as tumor invasion and metastasis. Therefore, it is considered an …

A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted
molecular properties such as enhanced stability or biological activity. It is a very powerful …

Angiogenesis refers to the process of remodeling the vascular tissue characterized by the
branching out of a new blood vessel from a pre‐existing vessel. Angiogenesis is particularly …

In view of the crucial role of protein-protein intercommunication both in biological and
pathological processes, the search of modulators of protein-protein interactions (PPIs) is …