Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

Background Metabolic disturbance has been reported in patients with epilepsy. Still, the
evidence about the causal role of metabolites in facilitating or preventing epilepsy is lacking …

We explore how functional genomics approaches that integrate datasets from human and
non-human model systems can improve our understanding of the effect of gene …

Background Metabolic disorders are a hallmark feature of cancer. However, the evidence for
the causality of circulating metabolites to promote or prevent colorectal cancer (CRC) is still …

The question of whether immune dysfunction contributes to risk of psychiatric disorders has
long been a subject of interest. To assert this hypothesis a plethora of correlative evidence …

Importance Certain psychiatric and immune-related disorders are reciprocal risk factors.
However, the nature of these associations is unclear. Objective To characterize the …

Genetically informed drug development and repurposing is an attractive prospect for
improving patient outcomes in psychiatry; however, the effectiveness of these endeavors is …

Varying combinations of genetic and environmental risk factors are thought to underpin
phenotypic heterogeneity between individuals in psychiatric conditions such as …

Retinol is a fat-soluble vitamin that plays an essential role in many biological processes
throughout the human lifespan. Here, we perform the largest genome-wide association …

Pneumonia remains one of the leading causes of death worldwide. In this study, we use
genome-wide meta-analysis of lifetime pneumonia diagnosis (N= 391,044) to identify four …