[HTML][HTML] Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics

H Chen, C Chen, M Spanos, G Li, R Lu, Y Bei… - … and Targeted Therapy, 2022 - nature.com
Exercise training has been widely recognized as a healthy lifestyle as well as an effective
non-drug therapeutic strategy for cardiovascular diseases (CVD). Functional and …

Understanding key mechanisms of exercise-induced cardiac protection to mitigate disease: current knowledge and emerging concepts

BC Bernardo, JYY Ooi, KL Weeks… - Physiological …, 2018 - journals.physiology.org
The benefits of exercise on the heart are well recognized, and clinical studies have
demonstrated that exercise is an intervention that can improve cardiac function in heart …

LncRNA ZFAS1 as a SERCA2a Inhibitor to Cause Intracellular Ca2+ Overload and Contractile Dysfunction in a Mouse Model of Myocardial Infarction

Y Zhang, L Jiao, L Sun, Y Li, Y Gao, C Xu… - Circulation …, 2018 - Am Heart Assoc
Rationale: Ca2+ homeostasis—a critical determinant of cardiac contractile function—is
critically regulated by SERCA2a (sarcoplasmic reticulum Ca2+-ATPase 2a). Our previous …

[HTML][HTML] MicroRNAs as important regulators of exercise adaptation

GJJ Silva, A Bye, H El Azzouzi, U Wisløff - Progress in cardiovascular …, 2017 - Elsevier
A significant body of evidence supports the protective role of exercise training (ET) in
cardiovascular diseases, skeletal muscle dystrophies, several types of cancer, Alzheimer …

[HTML][HTML] Exercise reduces insulin resistance in type 2 diabetes mellitus via mediating the lncRNA MALAT1/microRNA-382-3p/resistin axis

SX Liu, F Zheng, KL Xie, MR Xie, LJ Jiang… - … Therapy-Nucleic Acids, 2019 - cell.com
Insulin resistance (IR) is the primary pathological mechanism underlying type 2 diabetes
mellitus (T2DM). Here, the study aimed to ascertain whether and how exercise mediates IR …

[HTML][HTML] The effect of eight weeks resistance and endurance training on some angiogenesis factors of hippocampus tissue in male wistar rats

M Sadegh Ghomi, M Kashef… - Journal of Sport and …, 2021 - joeppa.sbu.ac.ir
Purpose: One of the cause of adaptations due to exercise training is increased capillary
density or angiogenesis. increased blood flow to hippocampus tissue causes improvement …

[HTML][HTML] مقایسة اثر تمرین تناوبی شدید و مقاومتی فزاینده بر بیان ژن ATF3 عضلة قلبی موش‌های صحرایی دیابتی نر

سفال منش, شهاب الدین, خالدی, ندا, رجبی… - نشریه فیزیولوژی ورزش و …, 2021‎ - joeppa.sbu.ac.ir
هدف: از سازوکارهای مؤثر در انجام بهتر عملکرد عضلانی در ورزشکاران، القای ظرفیت
پیش‌فعال‌سازی (PAP) در روش گرم کردن است. ازاین‌رو، پژوهش حاضر به‌منظور بررسی تأثیر گرم …

Endoplasmic Reticulum-Mitochondria Communication Through Ca2+ Signaling: The Importance of Mitochondria-Associated Membranes (MAMs)

S Marchi, M Bittremieux, S Missiroli, C Morganti… - Organelle Contact Sites …, 2017 - Springer
The execution of proper Ca 2+ signaling requires close apposition between the
endoplasmic reticulum (ER) and mitochondria. Hence, Ca 2+ released from the ER is “quasi …

[HTML][HTML] MicroRNAs in heart and circulation during physical exercise

L Wang, Y Lv, G Li, J Xiao - Journal of sport and health science, 2018 - Elsevier
Exercise training is beneficial to the cardiovascular system. MicroRNAs (miRNAs, miRs) are
a class of conserved non-coding RNAs and play a wide-ranging role in the regulation of …

MicroRNAs regulating signaling pathways in cardiac fibrosis: potential role of the exercise training

AC Improta-Caria, LF Rodrigues… - American Journal …, 2024 - journals.physiology.org
Cardiovascular and metabolic diseases such as hypertension, type 2 diabetes, and obesity
develop long-term fibrotic processes in the heart, promoting pathological cardiac …