Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …

Constitutive heterochromatin, mainly formed at the gene-poor regions of pericentromeres, is
believed to ensure a condensed and transcriptionally inert chromatin conformation …

Heat-shock transcription factor 1 (HSF1) orchestrates the fast and vast cellular response to
heat shock through increased expression of heat-shock proteins. However, how HSF1 …

Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute
stress. They are best known as inducible transcriptional regulators of genes encoding …

DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors.
However, for several decades after its independent discovery by two laboratories in 1983, it …

Replicative cellular senescence is an important tumor suppression mechanism and also
contributes to aging. Progression of both cancer and aging include significant epigenetic …

Despite the prominent role of TDP-43 in neurodegeneration, its physiological and
pathological functions are not fully understood. Here, we report an unexpected role of TDP …

Mammalian telomeres consist of non-coding TTAGGG repeats that are bound by the multi-
protein complex'shelterin', thus protecting chromosome ends from DNA repair mechanisms …

Various stress factors leading to protein damage induce the activation of an evolutionarily
conserved cell protective mechanism, the heat shock response (HSR), to maintain protein …

The premature aging disease Hutchinson–Gilford Progeria Syndrome (HGPS) is caused by
a mutant lamin A (LAΔ50). Nuclei in cells expressing LAΔ50 are abnormally shaped and …