Diabetes, metabolic disease, and telomere length

F Cheng, L Carroll, MV Joglekar… - The Lancet Diabetes & …, 2021 - thelancet.com
Telomeres are regions of repetitive nucleotide sequences at the ends of chromosomes.
Telomere length is a marker of DNA damage, which is often considered a biomarker for …

Precision prognostics for cardiovascular disease in type 2 diabetes: a systematic review and meta-analysis

A Ahmad, LL Lim, ML Morieri, CH Tam… - Communications …, 2024 - nature.com
Background Precision medicine has the potential to improve cardiovascular disease (CVD)
risk prediction in individuals with Type 2 diabetes (T2D). Methods We conducted a …

[HTML][HTML] Shortened leukocyte telomere length is associated with glycemic progression in type 2 diabetes: a prospective and mendelian randomization analysis

F Cheng, AO Luk, M Shi, C Huang, G Jiang… - Diabetes …, 2022 - Am Diabetes Assoc
OBJECTIVE Several studies support associations between relative leukocyte telomere
length (rLTL), a biomarker of biological aging and type 2 diabetes. This study investigates …

DNA Methylation-derived biological age and long-term mortality risk in subjects with type 2 diabetes

J Sabbatinelli, A Giuliani, KM Kwiatkowska… - Cardiovascular …, 2024 - Springer
Background Individuals with type 2 diabetes (T2D) face an increased mortality risk, not fully
captured by canonical risk factors. Biological age estimation through DNA methylation …

Relative leucocyte telomere length is associated with incident end-stage kidney disease and rapid decline of kidney function in type 2 diabetes: analysis from the …

F Cheng, AO Luk, H Wu, CHT Tam, CKP Lim, B Fan… - Diabetologia, 2022 - Springer
Aims/hypothesis Few large-scale prospective studies have investigated associations
between relative leucocyte telomere length (rLTL) and kidney dysfunction in individuals with …

Telomere length and metabolic syndrome traits: A Mendelian randomisation study

NY Loh, R Noordam, C Christodoulides - Aging Cell, 2021 - Wiley Online Library
Observational studies have revealed associations between short leucocyte telomere length
(LTL), a TL marker in somatic tissues and multiple Metabolic Syndrome (MetS) traits. Animal …

Investigating the impact of metabolic syndrome traits on telomere length: a Mendelian randomization study

NY Loh, D Rosoff, R Noordam, C Christodoulides - Obesity, 2023 - Wiley Online Library
Objective Observational studies have reported bidirectional associations between metabolic
syndrome (MetS) traits and short leukocyte telomere length (LTL), a TL marker in somatic …

Differential methylation of telomere-related genes is associated with kidney disease in individuals with type 1 diabetes

C Hill, S Duffy, LM Kettyle, L McGlynn, N Sandholm… - Genes, 2023 - mdpi.com
Diabetic kidney disease (DKD) represents a major global health problem. Accelerated
ageing is a key feature of DKD and, therefore, characteristics of accelerated ageing may …

Association of leukocyte telomere length with chronic kidney disease in East Asians with type 2 diabetes: a Mendelian randomization study

RL Gurung, R Dorajoo, L Wang, S Liu… - Clinical kidney …, 2021 - academic.oup.com
Background Chronic kidney disease (CKD) is common among people with type 2 diabetes
(T2D), and increases the risk of kidney failure and cardiovascular diseases. Shorter …

Beyond acute infection: molecular mechanisms underpinning cardiovascular complications in long COVID

RH Mostafa, A Moustafa - Frontiers in Cardiovascular Medicine, 2024 - frontiersin.org
SARS-CoV-2, responsible for the global COVID-19 pandemic, has manifested significant
cardiovascular implications for the infected population. These cardiovascular repercussions …