Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100
years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence …

Heparin, an old but first-line anticoagulant, has been used over a century. It is a
heterogeneous, linear, highly sulfated, anionic glycosaminoglycan with a broad distribution …

Carbohydrates play essential roles in nature, such as in cell–cell communication, cell growth
and immunoresponse. However, the synthesis of structurally well-defined carbohydrates …

Heparin, the most widely used anticoagulant drug, is mainly acquired from livestock.
Variable structures and contaminations of other glycosaminoglycans of animal-sourced …

Highlights•Metabolic engineering of heparosan, heparin and heparan sulfate•Chemical and
chemoenzymatic synthesis of low molecular weight heparins•Development of new heparin …

Here, we disclosed a convenient procedure for the preparation of EPP [3, 5-dimethyl-4-(2′-
phenylethynylphenyl) phenyl] glycosides and their application to an effective synthesis of …

Heparin and heparan sulfate represent key members of the glycosaminoglycan family of
carbohydrates and underpin considerable repertoires of biological importance. As such …

In the current study, new morpholine-linked thiazoles were prepared by the reaction of
salicylaldehyde derivative, thiosemicarbazide, and α-bromoketones. To mediate the …

Fondaparinux, a clinically approved anticoagulant pentasaccharide for the treatment of
thrombotic diseases, displays better efficacy and biosafety than other heparin-based …

Advances in polymer-based nanocomposites have revolutionized biomedical applications
over the last two decades. Heparin (HP), being a highly bioactive polymer of biological …