Autoimmune disorders are characterized as a condition in which the host's immune system
mistakenly attacks itself. These disorders cause the immune system to cause a systemic …

As one of the most abundant and well-studied epigenetic modifications, DNA methylation
plays an essential role in normal development and cellular biology. Global alterations to the …

When immunologic tolerance to auto-reactive immune cells is lost, autoimmune illness
manifests as the immune system attacking self-molecules. Numerous autoimmune diseases …

Exceptionally long-lived species, including many bats, rarely show overt signs of aging,
making it difficult to determine why species differ in lifespan. Here, we use DNA methylation …

The long non-coding RNA (lncRNA) XIST establishes X chromosome inactivation (XCI) in
female cells in early development and thereafter is thought to be largely dispensable. Here …

Increasing evidence suggests that long noncoding RNAs (lncRNAs) play crucial roles in
various biological processes. However, little is known about the effects of lncRNAs on …

The abnormal autophagy is associated with a variety of cardiovascular diseases. Long
noncoding RNAs (lncRNAs) are emerging as new factors in gene regulation, but how …

Introduction Mammalian genomes encode thousands of large noncoding RNAs (lncRNAs),
many of which regulate gene expression, interact with chromatin regulatory complexes, and …

It is likely that most vertebrate genes are associated with 'HTF islands'—DNA sequences in
which CpG is abundant and non-methylated. Highly tissue-specific genes, though, usually …

X-chromosome inactivation results in the cis-limited dosage compensation of genes on one
of the pair of X chromosomes in mammalian females. Although most X-linked genes are …