Aptamers from random sequence space: Accomplishments, gaps and future considerations
Aptamers are molecular recognition elements made of nucleic acids. Diverse synthetic
aptamers have been discovered in a large number of SELEX experiments since 1990. This …
aptamers have been discovered in a large number of SELEX experiments since 1990. This …
An overview of duplicated gene detection methods: Why the duplication mechanism has to be accounted for in their choice
T Lallemand, M Leduc, C Landès, C Rizzon, E Lerat - Genes, 2020 - mdpi.com
Gene duplication is an important evolutionary mechanism allowing to provide new genetic
material and thus opportunities to acquire new gene functions for an organism, with major …
material and thus opportunities to acquire new gene functions for an organism, with major …
Chapter 4: Protein interactions and disease
MW Gonzalez, MG Kann - PLoS computational biology, 2012 - journals.plos.org
Proteins do not function in isolation; it is their interactions with one another and also with
other molecules (eg DNA, RNA) that mediate metabolic and signaling pathways, cellular …
other molecules (eg DNA, RNA) that mediate metabolic and signaling pathways, cellular …
Classification and prediction of protein–protein interaction interface using machine learning algorithm
S Das, S Chakrabarti - Scientific reports, 2021 - nature.com
Structural insight of the protein–protein interaction (PPI) interface can provide knowledge
about the kinetics, thermodynamics and molecular functions of the complex while …
about the kinetics, thermodynamics and molecular functions of the complex while …
Patterns of positive selection in six mammalian genomes
Genome-wide scans for positively selected genes (PSGs) in mammals have provided insight
into the dynamics of genome evolution, the genetic basis of differences between species …
into the dynamics of genome evolution, the genetic basis of differences between species …
Converting peptides into drugs targeting intracellular protein–protein interactions
Highlights•Cyclic peptides are ideal inhibitors of protein–protein interactions (PPIs), due to
low immunogenicity and large surface area.•Peptide libraries are excellent tools to screen …
low immunogenicity and large surface area.•Peptide libraries are excellent tools to screen …
Himalayan bioactive molecules as potential entry inhibitors for the human immunodeficiency virus
VK Bhardwaj, R Purohit, S Kumar - Food Chemistry, 2021 - Elsevier
The human immunodeficiency virus interacts with the cluster of differentiation 4 receptors
and one of the two chemokine receptors (CCR5 and CXCR4) to gain entry in human cells …
and one of the two chemokine receptors (CCR5 and CXCR4) to gain entry in human cells …
Evolutionary Rate Covariation Identifies New Members of a Protein Network Required for Drosophila melanogaster Female Post-Mating Responses
Seminal fluid proteins transferred from males to females during copulation are required for
full fertility and can exert dramatic effects on female physiology and behavior. In Drosophila …
full fertility and can exert dramatic effects on female physiology and behavior. In Drosophila …
Bioinformatics approaches and big data analytics opportunities in improving fisheries and aquaculture
Aquaculture has witnessed an excellent growth rate during the last two decades and offers
huge potential to provide nutritional as well as livelihood security. Genomic research has …
huge potential to provide nutritional as well as livelihood security. Genomic research has …
Protein co‐evolution, co‐adaptation and interactions
F Pazos, A Valencia - The EMBO journal, 2008 - embopress.org
Co‐evolution has an important function in the evolution of species and it is clearly
manifested in certain scenarios such as host–parasite and predator–prey interactions …
manifested in certain scenarios such as host–parasite and predator–prey interactions …