EMT and inflammation: inseparable actors of cancer progression

M Suarez‐Carmona, J Lesage, D Cataldo… - Molecular …, 2017 - Wiley Online Library
Tumors can be depicted as wounds that never heal, and are infiltrated by a large array of
inflammatory and immune cells. Tumor‐associated chronic inflammation is a hallmark of …

Metadherin (AEG-1/MTDH/LYRIC) expression: significance in malignancy and crucial role in colorectal cancer

MTA Ghafar, NA Soliman - Advances in clinical chemistry, 2022 - Elsevier
Abstract Metadherin (AEG-1/MTDH/LYRIC) is a 582-amino acid transmembrane protein,
encoded by a gene located at chromosome 8q22, and distributed throughout the cytoplasm …

[HTML][HTML] COL1A1 promotes metastasis in colorectal cancer by regulating the WNT/PCP pathway

Z Zhang, Y Wang, J Zhang… - Molecular Medicine …, 2018 - spandidos-publications.com
Colorectal cancer (CRC) is the third leading cause of cancer‑associated mortality, and is a
major health problem. Collagen type I α 1 (COL1A1) is a major component of collagen type I …

[HTML][HTML] AEG-1 associates with metastasis in papillary thyroid cancer through upregulation of MMP2/9

LL Huang, Z Wang, CJ Cao, ZF Ke… - International …, 2017 - spandidos-publications.com
Abstract Astrocyte elevated gene-1 (AEG-1), known as an oncogene, is overexpressed in
various cancers and implicated in tumor progression and metastasis. However, its functional …

miR‐373‐3p Targets DKK1 to Promote EMT‐Induced Metastasis via the Wnt/β‐Catenin Pathway in Tongue Squamous Cell Carcinoma

J Weng, H Zhang, C Wang, J Liang… - BioMed Research …, 2017 - Wiley Online Library
MicroRNAs (miRNAs) regulate gene expression and at the same time mediate
tumorigenesis. miR‐373‐3p has diverse effects in tumors, but its role in tongue squamous …

[HTML][HTML] The scope of astrocyte elevated gene-1/metadherin (AEG-1/MTDH) in cancer clinicopathology: A review

M Khan, D Sarkar - Genes, 2021 - mdpi.com
Since its initial cloning in 2002, a plethora of studies in a vast number of cancer indications,
has strongly established AEG-1 as a bona fide oncogene. In all types of cancer cells …

[HTML][HTML] Multifunctional role of astrocyte elevated gene-1 (AEG-1) in cancer: focus on drug resistance

D Manna, D Sarkar - Cancers, 2021 - mdpi.com
Simple Summary Chemotherapy is a major mode of treatment for cancers. However, cancer
cells adapt to survive in stressful conditions and in many cases, they are inherently resistant …

[HTML][HTML] Daam1 activates RhoA to regulate Wnt5a‑induced glioblastoma cell invasion

G Liu, T Yan, X Li, J Sun, B Zhang… - Oncology …, 2018 - spandidos-publications.com
The signaling pathway of dishevelled-associated activator of morphogenesis 1 (Daam1)
triggered by Wnt5a drives cell movement and migration during breast cancer metastasis …

[HTML][HTML] Identification of COL1A1 associated with immune infiltration in brain lower grade glioma

J Ren, J Da, N Hu - Plos one, 2022 - journals.plos.org
Brain low grade gliomas (LGG) often give serious clinical symptoms due to the invasion
towards nervous system, affecting the life quality of patients. Collagen type I alpha 1 …

[HTML][HTML] An EMT-related genes signature as a prognostic biomarker for patients with endometrial cancer

Y Yu, Y Zhang, Z Li, Y Dong, H Huang, B Yang, E Zhao… - BMC cancer, 2023 - Springer
Background The epithelial-mesenchymal transition (EMT) plays an indispensable role in the
development and progression of Endometrial cancer (EC). Nevertheless, little evidence is …