• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive review was conducted on literature published through March 1, 2020. Searches …

Aim This executive summary of the valvular heart disease guideline provides
recommendations for clinicians to diagnose and manage valvular heart disease as well as …

Background Public health data signal increases in the number of people who inject drugs
(PWID) in the United States during the past decade. An updated PWID population size …

Background Hospitalizations due to medical and surgical complications of substance use
disorder (SUD) are rising. Most hospitals lack systems to treat SUD, and most people with …

Background There has been an increase in the prevalence of drug abuse (DA) in the
national opioid epidemic. With increasing DA, there is an increased risk of infective …

Background: Hospitalized patients with comorbid substance use disorders (SUDs) are at
high risk for poor outcomes, including readmission and emergency department (ED) use …

Background Rises in the incidence of bacterial infections, such as infective endocarditis (IE),
have been reported in conjunction with the opioid crisis. However, recent trends for IE and …