Background Individuals affected with autism often suffer additional co-morbidities such as
intellectual disability. The genes contributing to autism cluster on a relatively limited number …

Macroautophagy/autophagy is an evolutionarily highly conserved catabolic process that is
important for the clearance of cytosolic contents to maintain cellular homeostasis and …

Micro-electrode arrays (MEAs) are increasingly used to characterize neuronal network
activity of human induced pluripotent stem cell (hiPSC)-derived neurons. Despite their gain …

Childhood apraxia of speech (CAS), the prototypic severe childhood speech disorder, is
characterized by motor programming and planning deficits. Genetic factors make …

Cell identity is tightly controlled by specific transcriptional programs which require post-
translational modifications of histones. These histone modifications allow the establishment …

Here we ask: What is productive signaling? How to define it, how to measure it, and most of
all, what are the parameters that determine it? Further, what determines the strength of …

Genomic imprinting disorders are caused by the disruption of genomic imprinting processes
leading to a deficit or increase of an active allele. Their unique molecular mechanisms …

Pathogenic variants in ANKRD11 or microdeletions at 16q24. 3 are the cause of KBG
syndrome (KBGS), a neurodevelopmental syndrome characterized by intellectual disability …

Epigenetics, one mechanism by which gene expression can change without any changes to
the DNA sequence, was described nearly a century ago. However, the importance of …

Posttranslational modification of histones and related gene regulation are shown to be
affected in an increasing number of neurological disorders. SETD1A is a chromatin …