Cytokines that control the immune response were shown to have efficacy in preclinical
murine cancer models. Interferon (IFN)-α is approved for treatment of hairy cell leukemia …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Local immunotherapy ideally stimulates immune responses against tumors while avoiding
toxicities associated with systemic administration. Current strategies for tumor-targeted …

Abstract Ectodomain phosphatase/phosphodiesterase-1 (ENPP1) is overexpressed on
cancer cells and functions as an innate immune checkpoint by hydrolyzing extracellular …

After assessment of tumor histology, the next important factor to consider in the selection of a
chemotherapy regime is organ function. Patients who are to receive chemotherapy require …

These charts are primarily for reference but they allow US to make some preliminary
conclusions abotit the cflokine network:(l) Ail the cytokines in this list have growth factor …

Tumour-associated neutrophils can exert antitumour effects but can also assume a pro-
tumoural phenotype in the immunosuppressive tumour microenvironment. Here we show …

The pathophysiology of multiple sclerosis (MS) is characterised by fatigue, motor weakness,
spasticity, poor balance, heat sensitivity and mental depression. Also, MS symptoms may …

PURPOSE: PV701, a replication-competent strain of Newcastle disease virus, causes
regression of tumor xenografts after intravenous administration. This phase I study was …

Cytokines are soluble proteins that allow for communication between cells and the external
environment. Interferon (IFN) alpha, the first cytokine to be produced by recombinant DNA …