Osteoarthritis (OA) is a chronic, prevalent, debilitating joint disease characterized by
progressive cartilage degradation, subchondral bone remodeling, bone marrow lesions …

Abstract Background Mesenchymal stromal cells (MSCs) have attracted intense interest due
to their powerful intrinsic properties of self-regeneration, immunomodulation and multi …

Articular cartilage defects represent an inciting factor for future osteoarthritis (OA) and
degenerative joint disease progression. Despite multiple clinically available therapies that …

Exosomes are the small extracellular vesicles secreted by cells for intercellular
communication. Exosomes are rich in therapeutic cargos such as microRNA (miRNA), long …

Mesenchymal stromal cells nowadays emerge as a major player in the field of regenerative
medicine and translational research. They constitute, with their derived products, the most …

Osteoarthritis (OA) is a common degenerative joint disease that often involves progressive
cartilage degeneration and bone destruction of subchondral bone. At present, clinical …

Articular cartilage covers the surface of synovial joints and enables joint movement.
However, it is susceptible to progressive degeneration with age that can be accelerated by …

Background Secondary injury after spinal cord injury (SCI) is a major obstacle to their
neurological recovery. Among them, changes in astrocyte phenotype regulate secondary …

Osteoarthritis (OA) is a chronic degenerative disorder of the joint and its prevalence and
severity is increasing owing to ageing of the population. Osteoarthritis is characterized by …

To optimise the culture conditions for human Wharton's jelly-derived mesenchymal stem
cells (hWJ-MSCs) intended for clinical use, we investigated ten different properties of these …