Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of
continuous cell expansion until the cytomembrane ruptures, resulting in the release of …

DNA is proving to be a powerful scaffold to construct molecularly precise designer DNA
devices. Recent trends reveal their ever-increasing deployment within living systems as …

Patients with severe COVID-19 have a hyperinflammatory immune response suggestive of
macrophage activation. Bruton tyrosine kinase (BTK) regulates macrophage signaling and …

The inflammasome is a platform for inflammatory signaling, and the NLRP3 inflammasome
recognizes stimuli in vitro and in vivo, and releases inflammatory cytokines that trigger …

Aims The involvement of pyroptosis in ischemic stroke remains to be established. Therefore,
we used the specific pyroptosis inhibitor Vx765 as an experimental intervention target in a …

Vaccine adjuvants are applied to amplify the recipient's specific immune responses against
pathogen infection or malignancy. A new generation of adjuvants is being developed to …

Nod-Like Receptor (NLR) is the largest family of Pathogen Recognition Receptors (PRRs)
that patrols the cytosolic environment. NLR engagement drives caspase-1 activation that …

The combination of obesity and type 2 diabetes is a serious health problem, which is
projected to afflict 300 million people worldwide by 2020. Both clinical and translational …

Purinergic P2X7 receptor, a nonselective cation channel, is highly expressed in immune
cells as well as cardiac smooth muscle cells and endothelial cells. Its activation exhibits to …

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common
chronic liver disease worldwide. Its occurrence and progression involve the process from …