Alzheimer disease (AD) is a major cause of age-related dementia. We do not fully
understand AD aetiology and pathogenesis, but oxidative damage is a key component. The …

The blood‐brain barrier (BBB), as a crucial gate of brain‐blood molecular exchange, is
involved in the pathogenesis of multiple neurological diseases. Oxidative stress is caused …

Alzheimer's disease (AD) is the most common cause of memory impairment and dementia in
the elderly. AD is pathologically characterized by extracellular deposits of beta-amyloid (Aβ) …

Modulation of endogenous cellular defense mechanisms via the vitagene system represents
an innovative approach to therapeutic intervention in diseases causing chronic tissue …

Accumulating evidences reveal that cellular cholesterol deficiency could trigger the onset of
Alzheimer's disease (AD). As a key regulator, 24-dehydrocholesterol reductase (DHCR24) …

The blood-brain barrier (BBB) is a critical regulator of brain homeostasis. Additionally, the
BBB is the most significant obstacle to effective CNS drug delivery. It possesses specific …

The CNS is rich in cholesterol, which is essential for neuronal development and survival,
synapse maturation, and optimal synaptic activity. Alterations in brain cholesterol …

This retrospective review on discoveries of the roles of oxidative stress in brain of subjects
with Alzheimer disease (AD) and animal models thereof as well as brain from animal models …

Understanding mechanisms of aging and determinants of life span will help to reduce age-
related morbidity and facilitate healthy aging. Average lifespan has increased over the last …

Objectives. Aluminium, a neurotoxic agent in humans, has been implicated in the
pathogenesis of neurodegenerative disorders. In this study, we examined the behavioral …