Brain metastasis, which commonly arises in patients with lung cancer, breast cancer and
melanoma, is associated with poor survival outcomes and poses distinct clinical challenges …

Abstract The RAS–RAF–MEK–ERK signaling cascade is among the most frequently mutated
pathways in human cancer. Approximately 50% of melanoma patients possess a druggable …

Background Craniopharyngiomas, primary brain tumors of the pituitary–hypothalamic axis,
can cause clinically significant sequelae. Treatment with the use of surgery, radiation, or …

We report a comprehensive proteogenomics analysis, including whole-genome sequencing,
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …

Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

Recently, we described a machine learning approach for classification of central nervous
system tumors based on the analysis of genome-wide DNA methylation patterns [6]. Here …

Background Endoscopic skull‐base surgery (ESBS) is employed in the management of
diverse skull‐base pathologies. Paralleling the increased utilization of ESBS, the literature in …

Which genetic alterations drive tumorigenesis and how they evolve over the course of
disease and therapy are central questions in cancer biology. Here we identify 44 recurrently …

Craniopharyngiomas are rare, partly cystic and calcified embryonic malformations of the
sellar/parasellar region with low histological grade (WHO Io). A bimodal age distribution has …

The identification of mutationally activated BRAF in many cancers altered our conception of
the part played by the RAF family of protein kinases in oncogenesis. In this Review, we …