Molecular targeted therapies: ready for “prime time” in biliary tract cancer

A Lamarca, J Barriuso, MG McNamara, JW Valle - Journal of hepatology, 2020 - Elsevier
The prognosis for patients with biliary tract cancers (cholangiocarcinoma and gallbladder
cancer) is poor, while the incidence of these cancers is increasing. Most patients are …

Absorption, metabolism, anti-cancer effect and molecular targets of epigallocatechin gallate (EGCG): An updated review

RY Gan, HB Li, ZQ Sui, H Corke - Critical reviews in food science …, 2018 - Taylor & Francis
Green tea is one of the most popular beverages in the world, especially in Asian countries.
Consumption of green tea has been demonstrated to possess many health benefits, which …

Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion–Positive Cholangiocarcinoma

L Goyal, SK Saha, LY Liu, G Siravegna, I Leshchiner… - Cancer discovery, 2017 - AACR
Genetic alterations in the fibroblast growth factor receptor (FGFR) pathway are promising
therapeutic targets in many cancers, including intrahepatic cholangiocarcinoma (ICC). The …

Discovery and pharmacological characterization of JNJ-42756493 (Erdafitinib), a functionally selective small-molecule FGFR family inhibitor

TPS Perera, E Jovcheva, L Mevellec, J Vialard… - Molecular cancer …, 2017 - AACR
Fibroblast growth factor (FGF) signaling plays critical roles in key biological processes
ranging from embryogenesis to wound healing and has strong links to several hallmarks of …

[HTML][HTML] Pemigatinib: Hot topics behind the first approval of a targeted therapy in cholangiocarcinoma

A Rizzo, AD Ricci, G Brandi - Cancer Treatment and Research …, 2021 - Elsevier
Cholangiocarcinoma (CCA) includes a heterogeneous group of malignancies with limited
treatment options. Despite recent advances in medical oncology, the prognosis of CCA …

[HTML][HTML] FGF/FGFR signaling: From lung development to respiratory diseases

L Yang, F Zhou, D Zheng, D Wang, X Li, C Zhao… - Cytokine & Growth …, 2021 - Elsevier
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling system
regulates a variety of biological processes, including embryogenesis, angiogenesis, wound …

FGFR-TACC gene fusions in human glioma

A Lasorella, M Sanson, A Iavarone - Neuro-oncology, 2017 - academic.oup.com
Chromosomal translocations joining in-frame members of the fibroblast growth factor
receptor–transforming acidic coiled-coil gene families (the FGFR-TACC gene fusions) were …

Changing landscape of systemic therapy in biliary tract cancer

E Woods, D Le, BK Jakka, A Manne - Cancers, 2022 - mdpi.com
Simple Summary Cancers from the bile ducts and gall bladder are lethal. Cure by surgery is
not possible in most of these tumors as they are often identified in later stages. Unlike other …

The fibroblast growth factor receptors in breast cancer: from oncogenesis to better treatments

N Sobhani, C Fan, P O. Flores-Villanueva… - International journal of …, 2020 - mdpi.com
Breast cancer (BC) is the most frequent form of malignancy and second only to lung cancer
as cause of deaths in women. Notwithstanding many progresses made in the field …

[HTML][HTML] Detection of known and novel FGFR fusions in non–small cell lung cancer by comprehensive genomic profiling

A Qin, A Johnson, JS Ross, VA Miller, SM Ali… - Journal of Thoracic …, 2019 - Elsevier
Introduction Activation of the fibroblast growth factor receptor (FGFR) family through fusion
with various partners has been described in multiple cancer types, including NSCLC. FGFR …