Quality by design (QbD) has become an inevitable trend because of its benefits for product
quality and process understanding. Trials have been conducted using QbD in nanosystems' …

Delivery of nucleic acids with viral and synthetic vectors has pioneered genetic
nanomedicine. Four-component lipid nanoparticles (LNPs) consisting of ionizable lipids …

One-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimers
(IAJDs) were discovered in our laboratories in 2021 to represent a new class of synthetic …

Lipid drug conjugates (LDCs) are the chemical entities, which are commonly referred to as
lipoidal prodrug. They contain the bioactive molecules, covalently or non-covalently linked …

Viral and synthetic vectors to deliver nucleic acids were key to the rapid development of
extraordinarily efficient COVID-19 vaccines. The four-component lipid nanoparticles (LNPs) …

The combination of chemotherapy with the immune checkpoint blockade (ICB) therapy is
bringing a tremendous hope in the treatment of malignant tumors. However, the treatment …

Doxorubicin is a clinically important anthracycline chemotherapeutic agent that is used to
treat many cancers. Nanomedicine formulations including Doxil® and ThermoDox® have …

Liposomes have made remarkable achievements as drug delivery vehicles in the clinic.
Liposomal products mostly benefited from remote drug loading techniques that succeeded …

Four-component lipid nanoparticles (LNPs) and viral vectors are key for mRNA vaccine and
therapeutics delivery. LNPs contain ionizable lipids, phospholipids, cholesterol, and …

Glioblastoma multiforme (GBM), a prevalent brain cancer with high mortality, is resistant to
the conventional single-agent chemotherapy. In this study, we employed a combination …