Pirfenidone (PFD) is a non-peptide synthetic chemical that inhibits the production of
transforming growth factor-beta 1 (TGF-β1), tumor necrosis factor-alpha (TNF-α), platelet …

The overproduction of free radicals can cause oxidative-stress damage to a range of
biomolecules, and thus potentially contribute to several pathologies, from …

Fibrosis, also known as organ scarring, describes a pathological stiffening of organs or
tissues caused by increased synthesis of extracellular matrix (ECM) components. In the past …

Heparinases are enzymes that selectively cleave heparin and heparan sulfate chains, via
cleavage of the glycosidic linkage between hexosamines and uronic acids, producing …

Non-anticoagulant biological functions of heparin-based drugs have drawn increasing
attention. However, the exploration into the non-anticoagulant activities of various low …

Objective. The role of anticoagulants in chronic liver diseases is inconclusive. A meta‐
analysis was thus undertaken to evaluate treatment‐related survival and antifibrotic effects …

Heparan sulfate is a highly sulfated polysaccharide abundant on the surface of hepatocytes
and surrounding extracellular matrix. Emerging evidence demonstrates that heparan sulfate …

BACKGROUND Liver fibrosis progressing to liver cirrhosis and hepatic carcinoma is very
common and causes more than one million deaths annually. Fibrosis develops from …

Abstract Purpose of Review To revise experimental and clinical data supporting a less
traditional role of anticoagulation for treating portal hypertension in patients with cirrhosis …

目前包括肝脏在内的器官纤维化的研究发现, 凝血因素和炎症反应共同促进了脏器纤维化的进展
, 使人们认识到凝血因素的变化不仅仅是肝纤维化的继发性事件, 其在肝纤维化的发生发展中 …