In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore,
a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches …

Mitosis and cytokinesis are undoubtedly the most spectacular parts of the cell cycle. Errors in
the choreography of these processes can lead to aneuploidy or genetic instability, fostering …

The centromere is a chromosomal locus that ensures delivery of one copy of each
chromosome to each daughter at cell division. Efforts to understand the nature and …

Cancer cells contain abnormal number of chromosomes (aneuploidy), which is a prevalent
form of genetic instability in human cancers. Defects in a cell cycle surveillance mechanism …

There is increasing evidence that in eukaryotic cells, DNA undergoes continuous damage,
repair and resynthesis. A homeostatic equilibrium exists in which extensive DNA damage is …

The mitotic checkpoint protein hsMad2 is required to arrest cells in mitosis when
chromosomes are unattached to the mitotic spindle. The presence of a single, lagging …

Disrupted passage through mitosis often leads to chromosome missegregation and the
production of aneuploid progeny. Aneuploidy has long been recognized as a frequent …

The initiation of chromosome segregation at anaphase is linked by the spindle assembly
checkpoint to the completion of chromosome–microtubule attachment during metaphase. To …

In all eukaryotes, segregation of mitotic chromosomes requires their interaction with spindle
microtubules. To dissect this interaction, we use live and fixed assays in the one-cell stage …

Chromosome segregation is a complex and astonishingly accurate process whose inner
working is beginning to be understood at the molecular level. The spindle checkpoint plays …