[HTML][HTML] Structure-function-guided design of synthetic peptides with anti-infective activity derived from wasp venom
Antimicrobial peptides (AMPs) derived from natural toxins and venoms offer a promising
alternative source of antibiotics. Here, through structure-function-guided design, we convert …
alternative source of antibiotics. Here, through structure-function-guided design, we convert …
Macrophage targeting of nitazoxanide-loaded transethosomal gel in cutaneous leishmaniasis
Topical delivery is preferable over systemic delivery for cutaneous leishmaniasis, because
of its easy administration, reduced systemic adverse effects and low cost. Nitazoxanide …
of its easy administration, reduced systemic adverse effects and low cost. Nitazoxanide …
Co-delivery of amphotericin B and pentamidine loaded niosomal gel for the treatment of Cutaneous leishmaniasis
Topical drug delivery is preferable route over systemic delivery in case of Cutaneous
leishmaniasis (CL). Among the available agents, amphotericin B (AmB) and pentamidine …
leishmaniasis (CL). Among the available agents, amphotericin B (AmB) and pentamidine …
Statistically designed dexibuprofen loaded solid lipid nanoparticles for enhanced oral bioavailability
Abstract Dexibuprofen (DBPN), a non-steroidal anti-inflammatory drug (NSAID), exhibit its
action by inhibiting COX enzymes. It belongs to BCS class Ⅱ drugs, owing to its poor …
action by inhibiting COX enzymes. It belongs to BCS class Ⅱ drugs, owing to its poor …
Development and optimization of imiquimod-loaded nanostructured lipid carriers using a hybrid design of experiments approach
Background Imiquimod (IMQ) is an immunomodulating drug that is approved for the
treatment of superficial basal cell carcinoma, actinic keratosis, external genital warts and …
treatment of superficial basal cell carcinoma, actinic keratosis, external genital warts and …
Quality by design for sumatriptan loaded nano-ethosomal mucoadhesive gel for the therapeutic management of nitroglycerin induced migraine
Migraine is a progressive neurological condition often accompanied by nausea and
vomiting. Various drugs have recently been used in the treatment of migraine, including …
vomiting. Various drugs have recently been used in the treatment of migraine, including …
Statistical optimization of co-loaded rifampicin and pentamidine polymeric nanoparticles for the treatment of cutaneous leishmaniasis
Topical drug delivery against cutaneous leishmaniasis (CL) serves as an effective alternate
approach to improve efficacy and reduce systemic adverse effects. The purpose of this study …
approach to improve efficacy and reduce systemic adverse effects. The purpose of this study …
Metformin HCl-loaded transethosomal gel; development, characterization, and antidiabetic potential evaluation in the diabetes-induced rat model
Herein we designed, optimized, and characterized the Metformin Hydrochloride
Transethosomes (MTF-TES) and incorporate them into Chitosan gel to develop Metformin …
Transethosomes (MTF-TES) and incorporate them into Chitosan gel to develop Metformin …
Formulation and statistical optimization of letrozole loaded nanotransferosomal gel for tumor targeting
Letrozole (LTZ) is used as first-line treatment for hormone-positive breast cancer (BC) in
postmenopausal women. However, its poor aqueous solubility and permeability have …
postmenopausal women. However, its poor aqueous solubility and permeability have …
Mannosylated imiquimod-terbinafine co-loaded transethosomes for cutaneous leishmaniasis; assessment of its anti-leishmanial potential, in vivo safety and immune …
Current treatment options for cutaneous leishmaniasis are associated with myriad limiting
factors including low penetration, poor efficacy, and drug toxicities. Herein, we reported …
factors including low penetration, poor efficacy, and drug toxicities. Herein, we reported …