The mammalian central nervous system (CNS) requires the proper formation of exquisitely
precise circuits to function correctly. These neuronal circuits are assembled during …

This review highlights evidence for the nontransport functions of NHE1 and describes how
the structural functions are integrated with ion translocation to regulate a range of cellular …

BORC is a multisubunit complex previously shown to promote coupling of mammalian
lysosomes and C. elegans synaptic vesicle (SV) precursors (SVPs) to kinesins for …

Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological
disorders. It comprises a group of diseases caused by mutations in genes involved in …

The kinesin superfamily protein, KIF1Bβ, a splice variant of KIF1B, is involved in the
transport of synaptic vesicles in neuronal cells, and is also expressed in various non …

The c alcineurin h omologous p rotein (CHP) belongs to an evolutionarily conserved Ca2+-
binding protein subfamily. The CHP subfamily is composed of CHP1, CHP2, and CHP3 …

We studied the role of the interaction of calcineurin homologous protein 1 (CHP1) with the
Na+/H+ exchanger 1 (NHE1), particularly its EF-hand Ca2+ binding motifs, in the …

Calcineurin B homologous protein (CHP) 1 and 2 are Ca 2+-binding proteins that modulate
several cellular processes, including cytoplasmic pH by positively regulating plasma …

Na+/H+ exchanger 1 (NHE1) regulates intracellular pH, Na+ content, and cell volume.
Calcineurin B homologous protein 1 (CHP1) serves as an essential cofactor that facilitates …

To create a presynaptic terminal, molecular signaling events must be orchestrated across a
number of subcellular compartments. In the soma, presynaptic proteins need to be …